Bone Morphogenetic Proteins: An Overview

Anamika Sharma, Himani Sharma

Abstract


For over years research has been carried out for finding the treatment procedures for the regeneration of a lost or injured part so that form and function of lost structures can be restored.  This regenerative field holds the promise of engineering damaged tissues  with the help of various growth factors including Bone Morphogenetic Proteins (BMPs), by stimulating the body's own repair mechanisms. BMPs constitute the largest subgroup of transforming growth factor beta superfamily. Till date over 30 members of this family has been identified. They are dimeric molecules and exhibit their effects using specific cell surface receptors. With the development of the techniques required for the isolation and cloning of these molecules, we are now able to understand their properties. They are powerful inductors of the osteogenic activity and have proliferative effects on various cellular types. This made us to use them in various therapeutic procedures including oral maxillofacial reconstruction, periodontal regeneration, enhancing osseointegration around dental implants and in various endodontic procedures. However, their effect is dosage and carrier dependent. Thus, the aim of this review is to help in understanding the structure, classification, signaling and role of BMPs in regeneration of bone and tissues.

 

DOI: 10.21276/AABS.1336


Keywords


Bone Morphogenetic Proteins, regeneration, growth factors

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References


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