A Study of Transmission Transmitted Infections (TTI) prevalence in a large sample of 25,000 blood donors at a tertiary care center

  • Sheetal Arora ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
  • Deepshikha Rana ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
  • Varsha Chauhan ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
  • Shraddha Mishra Department of Pathology Safdarjung Hospital and VMMC New Delhi-110029
  • Dushyant S Rawat MBBS, MD (Pathology) Ex-Associate Professor Department Of Blood Bank Safdarjung Hospital and VMMC New Delhi-110029 Email id – dushyantsingh.rawat@gmail.com
Keywords: Co infections, Seroprevalence, Transfusion transmitted infections

Abstract

IntroductionBlood transfusion increases the risk of acquiring transfusion transmitted  infections  (TTI ).We  report  the  seroprevalence  of  hepatitis B (HBV),  hepatitis C(HCV), Human Immunodeficiency  Virus  (HIV),  syphilis  and malaria along with combined infections  in  2 years  .Material and methods A two-year retrospective study of 25,000 healthy blood donors.ResultsPrevalence of HIV, HBsAg, HCV and syphilis were 3.24%, 0.82%, 0.42%, 0.82% respectively. Twenty five (%) of these had co infection (>2TTIs).Of the 25 blood donors with co infections, fifteen were HIV seroreactive ,out of these nine were seroreactive with HBsAg , two were seroreactive with HCV and four with syphilis (VDRL).One donor was positive for HBsAg , HCV and HIV. Among ten HIV seronegative blood donors HBsAg and HCV seroreactivity was present in seven donors followed by HBsAg and STS in three.Discussion and Conclusion Seroprevalence of HCV is steady after 2006 as no effective vaccine is available against HCV infection.  High prevalence of HBsAg may be attributed to vaccine mutants or concealing of information by replacement donors.High prevalence of co-infection (0.1%) emphasizes the need for highly sensitive donor screening techniques, NAT, educational programs to enable detection of TTIs and decreasing transmission.DOI: 10.21276/AABS.1593

Author Biographies

Sheetal Arora, ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
RANK: ASSISTANT PROFESSORDEPARTMENT: PATHOLOGY
Deepshikha Rana, ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
RANK: POST M.D. TUTORDEPARTMENT: PATHOLOGY
Varsha Chauhan, ESIC MEDICAL COLLEGE AND HOSPITAL, FARIDABAD
RANK: POST M.D. TUTORDEPARTMENT: PATHOLOGY
Shraddha Mishra, Department of Pathology Safdarjung Hospital and VMMC New Delhi-110029
RANK: MBBS, M.D. Ex-Junior ResidentDepartment of Pathology
Dushyant S Rawat, MBBS, MD (Pathology) Ex-Associate Professor Department Of Blood Bank Safdarjung Hospital and VMMC New Delhi-110029 Email id – dushyantsingh.rawat@gmail.com
MBBS, MD (Pathology) Ex-Associate Professor Department Of Blood Bank

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Published
2017-08-18
Section
Original Article