Primary Breast Lymphoma: a rare case report with emphasis on role of cytology, cell block and tru-cut biopsy in diagnosis
Keywords:
Lymphoma, Primary breast lymphoma, Extranodal Lymphoma, FNAC, Cell-block, Immunohistochemistry
Abstract
Introduction: Primary breast lymphoma (PBL) is a rare tumour of breast and constitutes <0.6% of all breast malignancies and 2.2% of extranodal lymphomas. More than 80% of the PBL are B-cell Lymphoma, the most frequent being diffuse large B cell lymphoma.Case History: A sixty seven year old female presented with a 5X4 cm, firm, non-tender, mobile mass in lower-inner quadrant of left breast for last one month. Mammography suggested it to be a case of fibroadenoma. FNAC from the swelling diagnosed it as a case of Non-Hodgkin’s Lymphoma (NHL), with poorly differentiated ductal carcinoma as differential diagnosis. Cell block and tru-cut biopsy corroborated the FNAC findings. Immunohistochemistry definitely proved it to be a case of Primary Breast NHL.Conclusions: PBL can present as an innocuous lump. Early diagnosis is important for better prognosis. FNAC along with cell block, tru-cut biopsy with immunochemistry can diagnose a case and unnecessary surgical intervention can be avoided. We are reporting this case because it is a rare case and to emphasize on the role of FNAC, cell-block and tru-cut biopsy in diagnosis to prevent unnecessary mastectomies.References
1. Jeanneret-Sozzi W, Taghian A, Epelbaum R, Poortmans P, Zwahlen D, Amsler B, et al. Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study. BMC Cancer 2008;8:86.
2. Kim SH, Ezekiel MP, Kim RY. Primary lymphoma of the breast. Am J Clin Oncol 1999;22:381-83.
3. Zack RJ, Trevisan SG, Gupta M. Primary breast lymphoma originating in a benign intramammary lymph node. Am J Roentgenol 2001;177:177-8.
4. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer 1972;29:1705-12.
5. Jeon HJ, Akagi T, Hoshida Y, Hayashi K, Yoshino T, Tanaka T, et al. Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. Cancer 1992;70:2451-9.
6. Avenia N, Sanguinetti A, Cirocchi R, Bistoni G, Trastulli S, D'Ajello F, et al. Primary Breast Lymphoma, a multicentric experience. World J Surg Oncol 2010;8:53.
2. Kim SH, Ezekiel MP, Kim RY. Primary lymphoma of the breast. Am J Clin Oncol 1999;22:381-83.
3. Zack RJ, Trevisan SG, Gupta M. Primary breast lymphoma originating in a benign intramammary lymph node. Am J Roentgenol 2001;177:177-8.
4. Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer 1972;29:1705-12.
5. Jeon HJ, Akagi T, Hoshida Y, Hayashi K, Yoshino T, Tanaka T, et al. Primary non-Hodgkin malignant lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. Cancer 1992;70:2451-9.
6. Avenia N, Sanguinetti A, Cirocchi R, Bistoni G, Trastulli S, D'Ajello F, et al. Primary Breast Lymphoma, a multicentric experience. World J Surg Oncol 2010;8:53.
Published
2015-06-26
Issue
Section
Case Reports
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