Comparative Study of Fine Needle Non-Aspiration and Fine Needle Aspiration in Cytological Diagnosis of Thyroid Lesions

  • Manisha Sharma Sri Guru Ram Das Institute of Medical Sciences and Research
  • Mridu Manjari
  • Manas Madan
  • Taranveer Singh
  • Akanksha Singh
  • Tarunpreet Saini
Keywords: Thyroid, FNAC, FNNAC, Non-Aspiration Cytology

Abstract

Background:Fine needle aspiration (FNA) has been proven to be an important, simple, safe and first line investigation in evaluation of various thyroid lesions. But its efficacy is limited by presence of significant amount of blood in smears diluting the cellular yield. An alternate method fine needle non aspiration cytology (FNNAC) was developed which is less painful, easy to perform and shows better patient compliance. The present study was undertaken to compare the efficacy and quality of FNNAC with FNAC to determine whether it is a superior and the procedure of choice in vascular organs like thyroid.Methods: The study was done on 120 patients attending the cytology section in department of Pathology SGRDIMSAR, Amritsar. All of these patients had undergone FNAC and FNNAC simultaneously by single operator. The smears were scored using five parameters- background blood or clot, amount of cellular material, degree of cellular degeneration, degree of cellular trauma and retention of appropriate architecture by the pathologist without the prior knowledge of technique used. All the results were tabulated and were statistically interpreted using student t test .Results: Significant higher score favoured FNNAC for background blood (P<0.001), for cellular material and retention of architecture (P<0.012) over FNAC. For degree of cellular trauma and degeneration of material insignificant higher scores were observed. Total and average score favoured FNNAC over FNAC (P<0.001). Though FNAC yielded more diagnostically adequate samples but diagnostically superior case were higher in FNNAC smears.Conclusion: It was concluded that FNNAC offers better quality smears. FNAC yielded more adequate samples. Both the techniques are complimentary to each other and diagnostic accuracy can be enhanced by combining both the techniques.     

Author Biography

Manisha Sharma, Sri Guru Ram Das Institute of Medical Sciences and Research
Associate Professor, Department of Pathology

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Published
2016-12-15
Section
Original Article

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