A Descriptive Study of Histopathological Patterns of Lymph Node Biopsies In A Tertiary Care Hospital
Keywords:
Lymphadenopathy, biopsy, histopathological examination, diagnostic
Abstract
Background: Lymph node is affected by various types of lesions, both non-neoplastic (inflammatory) or neoplastic. Due to non-specific symptoms, the clinical diagnosis are usually delayed thus lymph node biopsy is mandatory to arrive at specific diagnosis for appropriate management.Objective: 1) To study the spectrum of lymph node pathology with clinical correlation.2) To study the different histological patterns of lymph node lesions and classify them into major categories.Material and Methods: The present study was a prospective observational type of study and included 331 patients who presented with lymph node enlargement in a tertiary care hospital over a period of 3 years from Jan 2013 to Dec 2015. Detailed clinical history was noted. The specimens were routinely processed and stained by Haematoxylin and eosin. Special stains along with immunohistochemistry were done whenever required.Result: A total of 331 lymph node biopsies were studied. Age distribution varied from 4 to 81 years with male to female ratio of 1:1.4. Non –neoplastic lesions comprised of maximum cases (80.06%) while neoplastic lesion were present in (19.93%) cases. Reactive lymphadenitis was the predominant non-neoplastic finding followed by granulomatous lymphadenitis. Neoplastic lesions were included 3.61% cases of lymphoma and 16.31% cases of metastatic lesions.Conclusion: Lymphadenopathy is not uncommon in our region so lymph node biopsy is an important tool for early diagnostic and prognostic purpose. Reactive lymphadenitis was the most common cause of lymphadenopathy followed by granulomatous lymphadenitis. DOI: 10.21276/APALM.1089References
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11) Vachhani A, Bhuva K, Jasani J, et al. Histopathological study of lymph node biopsy. International Journal of Biomedical and Advance Research 2013; 4 (11) : 790-5.
12) Rao MN, Raju YS, Prasad AK, et al. Evaluation of lymphadenopathy at a referral centre. JAPI ; 50 : 1488-1489.
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14) Reddy MP, Moorchung N, Choudhary A. Clinicopathological profile of pediatric lymphadenopathy. Ind J Paediatr 2002; 69 : 1047-1051.
15) Roy A, Kar R, Basu D, Badhe BA. Spectrum of histopathologic diagnosis of lymph node biopsies: a descriptive study from a tertiary care center in South India over 5½ years. Indian J Pathol Microbiol 2013; 56(2) : 103-8.
16) Sinclair S, Beckman E, Ellman L. Biopsy of enlarged superficial lymph nodes. JAMA 1974; 228(5): 602-603.
2) Sibanda EN, Stanczuk G. Lymph node pathology in Zimbabwe: A review of 2194 specimens. Q J Med 1993;86:811-7.
3) Moore SW, Schneider JW, Schaaf HS. Diagnostic aspects of cervical lymphadenopathy in children in the developing world: A study of 1877 surgical specimens. Pediatr Surg Int 2003;19:240-4.
4) Longo, Fuci et al, Harrison’s Internal Medicine 17th edition. Ch-60, p-370-372.
5) Kamat GC. A ten-year histopathological study of generalized lymphadenopathy in India. S Afr Fam Pract 2011; 53(3): 267-270.
6) Tiwari M, Aryal G, Shrestha R. Histopathologic diagnosis of lymph node biopsies. Nepal Med Coll J2007;9(4) : 259-61.
7) Kim LH, Peh SC, Chan KS. Pattern of lymph node pathology in a private pathology laboratory. Malays J Pathol 1999 ;21(2) :87-93.
8) Md Atiqur R, Md Mamun AB. Histopathological evaluation of lymph node biopsies: A hospital based study. J Enam Med Col 2012 ; 2(1) : 8-14.
9) Olu-Eddo AN, Ohanaka CE. Peripheral lymphadenopathy in Nigerian adults.J Pak Med Assoc 2006 ;56 : 405-8.
10) Saraswat A, Rajender A, Purohit K. Lymph node biopsy: Spectrum and clinical significance as diagnostic tool at tertiary care centre.J of Evolution Med and Dent Sci. 2015; 4(6): 1008-14.
11) Vachhani A, Bhuva K, Jasani J, et al. Histopathological study of lymph node biopsy. International Journal of Biomedical and Advance Research 2013; 4 (11) : 790-5.
12) Rao MN, Raju YS, Prasad AK, et al. Evaluation of lymphadenopathy at a referral centre. JAPI ; 50 : 1488-1489.
13) Mohan A, Reddy MK, Phaneendra BV, Chandra A. Aetiology of peripheral lymphadenopathy in adults: analysis of 1724 cases seen at a tertiary care teaching hospital in Southern India. Natl Med J India 2007; 20(2): 78-80.
14) Reddy MP, Moorchung N, Choudhary A. Clinicopathological profile of pediatric lymphadenopathy. Ind J Paediatr 2002; 69 : 1047-1051.
15) Roy A, Kar R, Basu D, Badhe BA. Spectrum of histopathologic diagnosis of lymph node biopsies: a descriptive study from a tertiary care center in South India over 5½ years. Indian J Pathol Microbiol 2013; 56(2) : 103-8.
16) Sinclair S, Beckman E, Ellman L. Biopsy of enlarged superficial lymph nodes. JAMA 1974; 228(5): 602-603.
Published
2017-04-02
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