Primary Neuroendocrine Carcinoma of Breast: an uncommon variant.
Keywords:
Neuroendocrine Carcinoma of breast, Endocrine tumor, Breast cancer, Histopathology
Abstract
Neuroendocrine carcinoma of breast ( NECB) is an aggressive variant of invasive mammary carcinoma. Very few cases of Primary NECB have been reported in the literature. Here we report a 50 year female presented with left breast lump measuring 15 x 12 cm. of gradual onset with left axillary lymphadenopathy. On fine needle aspiration cytology of breast and lymphnode were positive for malignant cells. On ultrasonography of abdomino- pelvis showed metastasis to liver, peri pancreatic and para aortic lymph nodes with minimal ascites. On histopathology reported as Primary NECB-Large cell type-left breast. We are presenting this case for its extreme rarity and aggressive clinical behaviour. DOI: 10.21276/APALM.1094References
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10) Stita W, Trabelsi A, Gharbi O, Mokni M, Korbi S. Primary solid neuroendocrine carcinoma of the breast Can J Surg 2009;52:E289-E290.
11) Hanna MY, Leung E, Rogers C, Pilgrim S. Primary large-cell neuroendocrine tumor of the breast. Breast J. 2013;19:204–206.
12) Wei B, Ding T, Xing Y, Wei W, Tian Z, Tang F, et al. Invasive neuroendocrine carcinoma of the breast: A distinctive subtype of aggressive mammary carcinoma. Cancer. 2010;116:4463–73.
2) Kim JW, Woo OH, Cho KR, Seo BK, Yong HS, Kim A, et al. Primary large cell neuroendocrine carcinoma of the breast: radiologic and pathologic findings. J Korean Med Sci 2008;23:1118-20.
3) Modlin IM, Lye K D, Kidd M. A five decade analysis of 13,715 carcinoid tumors. Cancer.2003;97:934-959.
4) David O, Bhattacharjee M. Diffuse neuroendocrine differentiation in a morphologically composite mammary infiltrating ductal carcinoma:a case report and review of literature. Arch Pathol Lab Med.2003;127(3):e131-4.
5) Ozbilim G, Kilicarslan B, Tezer E, Buyukkece A, Ustum M, Karaveli S et al. Breast carcinoma showing neuroendocrine differentiation characterized with ectopic hormone production (2 case report). Turk J Med Sci 2000;30:609-13.
6) Sapino A, Righi F, Cassoni P, Papitti M, Gugliotta P, Bussolati G. Expression of the neuroendocrine phenomenon in carcinoma of the breast. SeminDiagnPathol 2000;17:127-37.
7) Ellis IO, Schnitt SJ, Saste-Garau X. Invasive breast carcinoma. In: Tavassoli FA, Devilee P, editors. World Health Organization classification of tumours. Pathology and genetics of the tumours of breast and female genital organs. Lyon: IARC press;2003:13-59.
8) Tovosoli FA, Pathology of the breast. 1st ed. Norwalk: Connecticut. Appleton and Lange;2000.
9) Wang Jun, Bing Wei, Constance TA, et al. Invasive neuroendocrine carcinoma of breast: a population based study from the surveillance, epidemiology and end result (SEER) database, BMC cancer.2014;14:147.
10) Stita W, Trabelsi A, Gharbi O, Mokni M, Korbi S. Primary solid neuroendocrine carcinoma of the breast Can J Surg 2009;52:E289-E290.
11) Hanna MY, Leung E, Rogers C, Pilgrim S. Primary large-cell neuroendocrine tumor of the breast. Breast J. 2013;19:204–206.
12) Wei B, Ding T, Xing Y, Wei W, Tian Z, Tang F, et al. Invasive neuroendocrine carcinoma of the breast: A distinctive subtype of aggressive mammary carcinoma. Cancer. 2010;116:4463–73.
Published
2017-03-28
Issue
Section
Case Report
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