Extraskeletal Ewing sarcoma at rare sites with review of literature.
Keywords:
Extraskeletal Ewings Sarcoma, hard palate, lung, pleura
Abstract
Ewings sarcoma (ES) is mostly a tumour of children and young adults and is composed of densely distributed, uniform, small to medium sized, round cells with a high nuclear to cytoplasmic ratio. Extraskeletal ES (EES) is a rare presentation and we present 3 cases of EES at uncommon sites involving hard palate, lung and pleura. DOI: 10.21276/apalm.2017.1110References
1. Applebaum MA, Worch J, Matthay KK, et al. Clinical Features and Outcomes in Patients with Extra Skeletal Ewing Sarcoma. Cancer 2011; 117:3027-3032.
2. Batsakis JG, El-Naggar AK: Ewing's sarcoma and primitive neuroectodermal tumors; cytogenetic cynosures seeking a common histogenesis. Adv Anat Pathol 1997; 4:207-20.
3. El Weshi A, Allam A, Ajarim D, et al. Extraskeletal Ewing’s sarcoma family of tumours in adults: analysis of 57 patients from a single institution. Clin Oncol (R Coll Radiol) 2010; 22:374–381.
4. Tefft M, Vawter GF, Mitus A: Paravertebral "round cell" tumors in children. Radiology 1969;92:1501-1509
5. Ewing J. Classics in oncology. Diffuse endothelioma of bone. Proceedings of the New York Pathological Society, 1921. CA Cancer J Clin. 1972;22:95-98.
6. Lin PP, Wang Y, Lozano G. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma 2011:276463. http://dx.doi.org/10.1155/2011/276463
7. Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 2008; 20:412–418
8. Kissane JM, Askin FB, Nesbit M, Vietti T, Burgert Jr EO, Cangir A, Gehan EA, Perez CA, Pritchard DJ, Tefft M: Sarcomas of bone in childhood. Pathologic aspects. In Glicksmann A, Tefft M (eds): Bone and soft tissue sarcomas. J Natl Cancer Inst Monograph 1981; 56:29-41.
9. Hafezi S, Seethala RR , Edward B. Stelow EB, Mills SE, Leong IT, MacDuff E, Hunt JL, Ordoñez BP, Weinreb I. Ewing’s Family of Tumors of the Sinonasal Tract and Maxillary Bone.Head Neck Pathol. 2011; 5(1): 8–16.
10. Javery O, Regan K O, Jagannathan J, Krajewski K, Giardino A, Ramaiya N H, Kis B. A to Z of Extraskeletal Ewing Sarcoma Family of Tumors in Adults: Imaging Features of Primary Disease, Metastatic Patterns, and Treatment Responses. American Journal of Roentgenology 2011;197:1015-1022. doi10.2214/AJR.11.6667.
11. Pinto A, Dickman P, Parham D. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors:State of the Art and Prediction of Behaviour. Sarcoma, vol. 2011, Article ID 856190, 15 pages, 2011. doi:10.1155/2011/856190
12. Bridge JA, Dembinski A, DeBoer J, Travis J, Neff JR: Clonal chromosomal abnormalities in osteofibrous dysplasia. Cancer 1994,73:1746-52.
13. Weiss SW, Goldblum JR. Enzinger and Weiss's soft tissue tumors. 4th edn. St. Louis: Mosby Inc; 2001. p. 1303.
14. Dickman PS, Triche TJ: Ultrastructural comparison of Ewing's sarcoma of bone with diverse pediatric soft tissue sarcoma resembling Ewing's sarcoma. Lab Invest 1981;44:15-16.
15. Maki RG. Pediatric sarcomas occurring in adults. J Surg Oncol 2008; 97:360–368
2. Batsakis JG, El-Naggar AK: Ewing's sarcoma and primitive neuroectodermal tumors; cytogenetic cynosures seeking a common histogenesis. Adv Anat Pathol 1997; 4:207-20.
3. El Weshi A, Allam A, Ajarim D, et al. Extraskeletal Ewing’s sarcoma family of tumours in adults: analysis of 57 patients from a single institution. Clin Oncol (R Coll Radiol) 2010; 22:374–381.
4. Tefft M, Vawter GF, Mitus A: Paravertebral "round cell" tumors in children. Radiology 1969;92:1501-1509
5. Ewing J. Classics in oncology. Diffuse endothelioma of bone. Proceedings of the New York Pathological Society, 1921. CA Cancer J Clin. 1972;22:95-98.
6. Lin PP, Wang Y, Lozano G. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma 2011:276463. http://dx.doi.org/10.1155/2011/276463
7. Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 2008; 20:412–418
8. Kissane JM, Askin FB, Nesbit M, Vietti T, Burgert Jr EO, Cangir A, Gehan EA, Perez CA, Pritchard DJ, Tefft M: Sarcomas of bone in childhood. Pathologic aspects. In Glicksmann A, Tefft M (eds): Bone and soft tissue sarcomas. J Natl Cancer Inst Monograph 1981; 56:29-41.
9. Hafezi S, Seethala RR , Edward B. Stelow EB, Mills SE, Leong IT, MacDuff E, Hunt JL, Ordoñez BP, Weinreb I. Ewing’s Family of Tumors of the Sinonasal Tract and Maxillary Bone.Head Neck Pathol. 2011; 5(1): 8–16.
10. Javery O, Regan K O, Jagannathan J, Krajewski K, Giardino A, Ramaiya N H, Kis B. A to Z of Extraskeletal Ewing Sarcoma Family of Tumors in Adults: Imaging Features of Primary Disease, Metastatic Patterns, and Treatment Responses. American Journal of Roentgenology 2011;197:1015-1022. doi10.2214/AJR.11.6667.
11. Pinto A, Dickman P, Parham D. Pathobiologic Markers of the Ewing Sarcoma Family of Tumors:State of the Art and Prediction of Behaviour. Sarcoma, vol. 2011, Article ID 856190, 15 pages, 2011. doi:10.1155/2011/856190
12. Bridge JA, Dembinski A, DeBoer J, Travis J, Neff JR: Clonal chromosomal abnormalities in osteofibrous dysplasia. Cancer 1994,73:1746-52.
13. Weiss SW, Goldblum JR. Enzinger and Weiss's soft tissue tumors. 4th edn. St. Louis: Mosby Inc; 2001. p. 1303.
14. Dickman PS, Triche TJ: Ultrastructural comparison of Ewing's sarcoma of bone with diverse pediatric soft tissue sarcoma resembling Ewing's sarcoma. Lab Invest 1981;44:15-16.
15. Maki RG. Pediatric sarcomas occurring in adults. J Surg Oncol 2008; 97:360–368
Published
2017-02-17
Issue
Section
Case Report
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