A Cytohistopathological Correlation of Thyroid Lesions with Critical Evaluation Of Discordant Cases: An Experience At A Tertiary Care Hospital

  • Shakuntala Sunil Aramani Gadag Institute Of Medical Sciences
  • Gururajaprasad C
Keywords: Thyroid, Histopathological Correlation, FNAC, Sensitivity, Specificity, Diagnostic accuracy

Abstract

Background: Fine Needle Aspiration Cytology (FNAC)  is important for pre-operative diagnosis of benign and malignant thyroid lesions. It is usually the first line of investigation and a minimally invasive diagnostic procedure whose essential role is to diagnose and distinguish benign from malignant lesions. Thus the present study was undertaken to determine sensitivity, specificity and accuracy of  FNAC in the diagnosis of thyroid lesions and to correlate cytological findings with histopathology.Methods: A prospective study was conducted in a tertiary care centre to study FNAC of thyroid lesions along with its histopathological correlation over a period of 2 years starting from June 2013 to June 2015Result: 56(93%) patients were females and 4(7%) patients were males. Patients age ranged from 15 to 65 years .Commonest lesion encountered in thyroid gland was colloid goitre, while papillary carcinoma was the most frequent malignant lesion. Cyto-histopathological correlation of 60 cases was done. Sensitivity ,specificity and diagnostic accuracy of the study for malignant lesions was 96.36%,100%,and 96.66% respectively.Conclusion: FNAC is a safe, simple, highly accurate, economical method for evaluation of palpable thyroid lesions. There is almost perfect cyto-histopathological concordance and the results are consistent with those available in the literature. FNAC helps in avoiding unnecessary surgeries in patients diagnosed to have a benign pathology based on cytology. Thus FNAC serves as a useful screening test to triage thyroid lesions before surgery. DOI: 10.21276/APALM.1154 

Author Biography

Shakuntala Sunil Aramani, Gadag Institute Of Medical Sciences
Dept of pathologyAssistant Professor

References

1. Agrawal R, Saxena M, Kumar P. A Study of Fine Needle Aspiration Cytology of Thyroid Lesions with Histopathological Correlation. Indian Journal of Pathology and Oncology.2015;2(4):277-283
2. Bakhos R, Selvaggi SM, DeJong S, Gordon DL, Pitale SU, Herrmann M and Wojcik EM. Fine-needle aspiration of the thyroid: Rate and causes of cytohistopathologic discordance. Diagn. Cytopathol.2000;23(4): 233–237
3. Gamit MJ, Talwelkar SR, Dhruva GA. Histocytological Correlation Study of Thyroid Gland Lesions.International Journal of Science and Research. Nov 2015;4(11):777-780.
4. Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA et al. Long‐term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer Cytopathology. 2007 Dec 25;111(6):508-16.
5. Gupta M, Gupta S, Gupta VB. Correlation of fine needle aspiration cytology with histopathology in the diagnosis of solitary thyroid nodule. Journal of thyroid research. 2010 Apr 18;2010.
6. Pandey P, Dixit A, Mahajan NC. Fine-needle aspiration of the thyroid: A cytohistologic correlation with critical evaluation of discordant cases. Thyroid Research and practice. 2012 May ;9(2):32-39
7. Parikh UR, Goswami HM, Shah AM, Mehta NP, Gonsai RN. Fine needle aspiration cytology (FNAC) study of thyroid lesions (study of 240 cases). GMJ. 2012;67(2):25-8.
8. Tilak V. Dhaded AV, Jam R. Fine needle aspiration cytology of head and neck masses. Indian J Pathol Microbiol. 2002 Jan; 45(1):23-9.
9. Kumar SK, Seetharamaiah T, Rampure D, Ramakrishna C, Devi RY. Thyroid nodule: Cytohistological correlation. Scholar J Appl Med Sci.2013;1(6):745-747
10. Amatya BB, Joshi AR, Singh SK, Panth R, Basnet RB. A study of fine needle aspiration cytology of head and neck masses and their corroboration by histopathology. Post graduate medical journal of national academy of medical sciences. 2009;6(2).
11. Fernandes H, D’Souza CRS, Thejaswini BN. The role of fine needle aspiration cytology in palpable head and neck masses. Journal of clinical and diagnostic research. 2009 Oct; (3):1719-1725.
12. Gagneten CB, Roccataglinta G, Lowenstein A et al. The role of fine needle aspiration biopsy cytology in the evaluation of the clinically solitary thyroid nodule. Acta Cytologica. 1987;31:595-598
13. Hsu CH, Boey J, Diagnostic pitfalls in the fine needle aspiration of thyroid nodules. A study of 555 cases in Chinese patients. Acta Cytologica.1986Dec;31(6): 699-704.
14. Goellner JR, Gharib H, Grant CS, Johnson DA. Fine needle aspiration cytology of the thyroid,1980 to 1986.Acta Cytologica.1986Dec;31(5): 587-90
15. OreIl SR, Sterrett GF, Walters MN-I, Whitaker D. Manual and atlas of fine-needle aspiration cytology, The thyroid gland. Third edition : Churchill Livingstone, 2003: 110 -140.
16. Orell SR, Sterrett GF, Whitaker D et al: The thyroid gland. In Manual and atlas of fine- needle aspiration cytology, 2nd Edn: Churchill Livingstone,1992:102-104
17. Lowhagen T, Sprenger E. Cytologic presentation of thyroid tumors in aspiration biopsy smear. A review of 60 cases. Acta Cytologica.1974;18(3):192-197.
Published
2017-06-04
Issue
Vol 4 No 3 (2017)
Section
Original Article

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