Cytological and Histomorphological Correlation of Salivary Gland Lesions- An Experience at Rural Tertiary Healthcare Hospital

  • Thangam R Department of Pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry
  • Vaishali Dhananjay Kotasthane Department of Pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry
  • Dhananjay Shrikant Kotasthane Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
  • Koteeswaran G Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
  • N S Kannan Department of General Surgery,Sri Manakula Vinayagar Medical College and Hospital,Pondicherry,India
Keywords: Fine Needle Aspiration Cytology, Histopathology, Salivary glands

Abstract

BACKGROUND: Salivary gland tumours account for 3-10% of all the head and neck neoplasm. FNAC is being increasingly used in the diagnosis of salivary gland tumours. The objective of this study was to evaluate the age, sex and site distribution and to evaluate the diagnostic accuracy of fine needle aspiration cytology (FNAC) in various   salivary gland lesions in correlation with their histopathology, which helps in appropriate management of the patient.METHODS AND MATERIAL: The present study was done at the pathology department,  Mahatma Gandhi Medical College and Research Institute, Pondicherry. FNAC was done using 22 gauge needle and 10 ml syringe and smears were stained with H&E and Giemsa stains. Histopathology was assessed on routine H&E stained paraffin sections .Cyto-histo correlation was done and overall diagnostic accuracy, sensitivity and specificity were calculated.RESULTS: The study was conducted on 122  patients having  salivary gland lesions .The age ranged from 24-80 years. Benign tumours were common in 3rd  decade, whereas malignant tumours in 6th  decade of life. There was female preponderance with male to female ratio of 1:1.03.Parotid glands were commonly involved in 74(78.72%).Out of 94 neoplastic cases,78(82.97%)were benign and  14(14.89%) were malignant. Pleomorphic adenoma was the commonest lesion observed accounted for 68.08%.CONCLUSION: The Overall sensitivity, specificity and diagnostic accuracy  were 80%, 94.74% and 91.66% respectively. FNAC of the salivary gland is safe, rapid ,accurate and reliable technique in the primary diagnosis of salivary gland lesions and useful in avoiding surgery (in inflammatory lesions) or limiting surgical procedures (in benign tumours) DOI: 10.21276/APALM.1278

Author Biographies

Thangam R, Department of Pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry
Postgraduate Student ,Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
Vaishali Dhananjay Kotasthane, Department of Pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry
Assistant professor, Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
Dhananjay Shrikant Kotasthane, Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
Professor and HOD,Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
Koteeswaran G, Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
Professor,Department of pathology,Mahatma Gandhi Medical College and Research Institute,Pillaiyarkuppam,Pondicherry-Cuddalore Main road,Pondicherry 607402
N S Kannan, Department of General Surgery,Sri Manakula Vinayagar Medical College and Hospital,Pondicherry,India
professor,Department of General Surgery,Sri Manakula Vinayagar Medical College and Hospital,Pondicherry,India

References

1. Stenner M, Klussmann JP. Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved. Eur Arch Otorhinolaryngol. 2009 Mar. 266(3):333-41.
2. Zbaren P, Nuyens M, Loosli H, Stauffer E. Diagnostic Accuracy of fine needle aspiration cytology and Frozen section in primary parotid carcinoma. Cancer 2004;9(100):1876-81.
3. Nanda S KD, Mehta A, Nanda J. Fine needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. Journal of oral pathology & medicine 2012;41(1):106-112.
4. Wong DSY, Li GKH. The role of fine-needle aspiration cytology in the management of parotid tumors: a critical clinical appraisal. Head Neck 2000; 22:469–473.
5. Zbaren P, Schar C, Hotz MA, Loosli H. Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 2001;111:1989–1992.
6. Rau AR, Pai RR, Nayak S. Infarction of acinic cell carcinoma in a patient infected with HIV: A complication of fine-needle aspiration cytology obscuring definitive diagnosis. Diagn Cytopathol 2001; 24: 301-303.
7. Pabuccuoglu HU, Lebe B, Sarioglu S, Lebe E. Infarction of pleomorphic adenoma: A rare complication of fine-needle aspiration obscuring definitive diagnosis. Diagn Cytopathol 2003; 29: 222-224.
8. Shintani S, Matsuura H, Hasegawa Y. Fine needle aspiration of salivary gland tumors Int J Oral Maxillofac Surg 1997; 26: 284- 286.
9. Ahmad S, Lateef M, Ahmad R. Clinicopathological study of primary salivary gland tumors in Kashmir. JK- Practitioner 2002; 9: 231- 33
10. Vaidhya S, Sinha. A, Narayan. S, Adhikari. S, Sabira. KC. A comparative study of fine-needle aspiration cytology and histopathology in salivary gland lesions. Journal of pathology of Nepal 2011;108-113.
11. Klijanienko J, Vielh P. Fine needle sampling of salivary gland lesions IV .Review of 50 cases of mucoepidermoid carcinoma with histologic correlation .Diagn cytopathol 1997;17:92-8
12. Yu GH, Caraway NP. Poorly-differentiated adenoid cystic carcinoma:cytologic appearance in fine-needle aspirates of distant metastases. Diagn cytopathol 1996;15:296-300.
13. Veder L, Kerrebijn JD, Smedts FM, den Bakker MA. Diagnostic accuracy of fine-needle aspiration cytology in Warthin tumors. Head Neck. 2010;32(12):1635-40
14. Dodd LG, Caraway NP, Luna MA, Byers PM. Myoepithelioma of the parotid. Report of a case initially examined by fine needle aspiration biopsy. Acta cytol 1994;38:417-21
15. Sousa J, Desa O. Salivary gland tumors : An analysis of 62 cases. Cancer 2001; 38: 38- 45.
16. Khandekar MM, Kavatkar AN, Patankar SA. FNAC of salivary gland lesions with histopathological correlation .J Otolaryngol and Head and Neck Surg 2006; 58: 246- 48.
17. Kapadia SB, Dusenbery D, Dekker A. Fine needle aspiration of pleomorphic adenoma and adenoid cystic carcinoma of salivary gland origin. Acta Cytol 1997; 41: 487- 92.
18. Lee SS, Cho KJ Jang JJ, et al. Differential diagnosis of adenoid cystic carcinoma from pleomorphic adenoma of the salivary gland on fine needle aspiration cytology. Acta Cytol 1996; 40: 1246
19. Haberal I, Golmen H, Safak MA, et al. The value of fine needle aspiration biopsy in salivary gland tumors. International Congress Series 2003; 629- 34
20. Zakowski MF. Fine needle aspiration cytology of tumors: Diagnostic accuracy and potential pitfalls. Cancer Invest 1994; 12: 505-515.
21. Chan MKM, Mc Guire LJ, King W, Li AKC, Lee JCK. Cytodiagnosis of 112 salivary gland lesions, correlation with histologic and frozen section diagnosis. Acta Cytol 1992; 36: 353- 363.
Published
2017-04-19
Section
Original Article