Intra-cystic papillary neoplasm of salivary gland with focal low grade malignant change: a rare entity.
Keywords:
Salivary Glands, Intraductal Papillary Tumor, Low-Grade Malignant
Abstract
Intraductal papilloma is a rare benign salivary gland tumor. It is found in the duct of the minor salivary glands, predominantly in lip and buccal mucosa, but the tumors in the sublingual region are quite rare. Malignant counterpart of intraductal papilloma which is a well defined entity in WHO classification is also extremely rare. This report shows a case of borderline intraductal papillary tumor with low malignant potential. It developed in minor salivary gland of sublingual region. This is a very rare entity, not included in WHO classification of salivary gland tumors and needs to be distinguished from other more common papillary and cystic tumors found in salivary glands.References
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2) Nagao T, Sugano I, Matsuzaki O, Hara H, Kondo Y, Nagao K. Intraductal Papillary Tumors of the Major Salivary Glands: Case Reports of Benign and Malignant Variants. Arch Pathol Lab Med.2000; 124:291-5.
3) Caramanico L, Marcone P, Rovere P, Rocca CD. Intraductal Papillary Carcinoma of the Parotid Gland with Low Malignancy. Pathology- research and practice. 1999; 195: 253–56.
4) Jamal AM, Sun ZJ, Chen XM, Zhao YF. Salivary duct carcinoma of the parotid gland: case report and review of the lîterature. J Oral Maxillofac Surg. 2008; 66: 1708-13.
5) Delgado R, Vuitch F. Salivary duct carcinoma. Cancer.1993;72:1503-12.
6) Nagao T, Gafey TA. Invasive rnicropapillary salivary duct carcinoma. A distinct histologic variant with biologic significance. Am J Surg Pathol. 2004; 28: 319-26.
7) de Sousa SO, Sesso A, de Araújo NS, et al. Inverted ductal papiloma of minor salivary gland origin: morphological aspects and cytokeratin expression. Eur Arch Otorhinolaryngol. 1995; 252: 370–73.
8) Delgado R, Klimastra D. Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattem. Cancer. 1996; 78: 958-67.
9) Lin WL, Ho MC, Chao WR. High-grade salivary duct carcinoma of the parotid gland- case report. J Denl Sci. 2008; 3: 222-27.
10) Nagao T, Watanabe A. Sarcomatoid variant of salivary duct carcinoma. Clinicopathologic and immunoistochemical study of eight cases with review of the literature. Am J Clin Pathol. 2014; 122: 222-31.
Published
2015-07-21
Issue
Section
Case Report
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