Lymphoepithelioma-like carcinoma of the breast: A case report

  • Trupti R Jansari The Gujarat Cancer and Research Institute, Ahmedabad.
  • Tanvi Gupta The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
  • Priti Trivedi The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
  • Manoj J Shah The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
Keywords: Breast, Differential diagnosis, Lymphoepithelioma-like carcinoma.

Abstract

Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma, it occurs in the organs that exclude nasopharynx, but has the same morphology as that of nasopharangeal lymphoepithelioma. It has been described in several organs, however it is rarely seen in the breast. Due to the undifferentiated appearance of neoplastic cells and the presence of prominent lymphocytic infiltrate, LELC can wrongly be diagnosed as lymphoma and medullary carcinoma. In this case, we present the LELC of the breast in a 39 year-old woman with clinical, histological and immunohistochemical features with differential diagnosis.

Author Biographies

Trupti R Jansari, The Gujarat Cancer and Research Institute, Ahmedabad.
Pathology
Tanvi Gupta, The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
Pathology
Priti Trivedi, The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
Pathology
Manoj J Shah, The Gujarat Cancer And Research Institute, Ahmedabad, Gujarat, India
Pathology

References

1. Naidoo P, Chetty R. Lymphoepithelioma-like carcinoma of the breast with associated sclerosing lymphocytic lobulitis. Arch Pathol Lab Med 2001;125: 669-72.

2. Kucukzeybek BB, Postaci H, Ozguzer A, Yakan S, Denecli AG. Lymphoepithelioma-like Carcinoma of the Breast: A Case Report and Review of the Literature. Int J of Hematol and Oncol; 2011:21:115-119

3. Dinniwell R, Hanna W et al. Lymphoepithelioma-like carcinoma of the breast: a diagnostic and therapeutic challenge. CurrOncol 2012;19: 177-183.

4. Kumar S, Kumar D. Lymphoepithelioma-like carcinoma of the breast. Mod Pathol 1994;7: 129-31.

5. Kurose A, Ichinohasama R, Kanno H, et al. Lymphoepithelioma- like carcinoma of the breast. Report of a case with the first electron microscopic study and review of the literature. Virchows Arch 2005;447: 653-659.

6. Ilvan S, Celik V, Akyildiz EU, et al. Lymphoepitheliomalikecarcinoma of the breast: is it a distinct entity? Clinicopathologicalevaluation of two cases and review of the literature. The Breast 2004; 13: 522-26.

7. Dadmanesh F, Peterse JL, Sapino A, et al. Lymphoepithelioma-like carcinoma of the breast: lack of evidence of Epstein–Barr virus infection. Histopathology 2001;38: 54-61.

8. Pestereli HE, Erdogan O, Kaya R, Karaveli FS. Lymphoepithelioma-like carcinoma of the breast.A newly recognized subtype of lobular carcinoma. APMIS 2002;110: 447-450.
Published
2015-10-28
Issue
Vol 2 No 4 (2015)
Section
Case Report

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).