Spectrum of histomorphological changes in lungs at autopsy: A 5 year study
Keywords:
Lung Autopsy, Histomorphological changes, Pneumonia, Tuberculosis, Terminal changes, Chronic respiratory diseases.
Abstract
Background: An autopsy is an essential and most beneficial way to find out state of the internal organs. Various inflammatory, neoplastic and other lesions along with almost all forms of terminal diseases complicate lungs. Autopsy can disclose the disease that may not be suspected clinically or may offer understanding of previous disease. Methods: This is the non-interventional record based cross-sectional study done in the Department of Pathology of North Maharashtra regional center. Cases were included irrespective of their age and sex. 1263 cases were studied during the period of January 2011 to December 2015. Gross and microscopic features were documented.Result: Amongst 1263 cases studied during the period of five years, maximum cases were seen in 20-29 years of age group. Males were more commonly affected (56.13%) compared to females (43.86%). Terminal changes like pulmonary edema and changes due to cardiac causes were most commonly (58.82%) seen in lungs at autopsy, followed by pneumonia (19.16%). Sickle cell disease, tuberculosis, acute respiratory distress syndrome and mycotic abscess accounted for 3.24%, 2.53%, 0.55% and 0.23% cases respectively. 0.39% cases showed metastatic lung cancer. Among the cases of pneumonia, interstitial pneumonia was most common (42.56%), presented most commonly in 20-29 years of age group with male preponderance (22.31%).Conclusion: Autopsy remains vital even after significant progress in diagnostic technologies. It is an important complimentary tool in identifying and understanding respiratory diseases that also helps in evaluating the disease process. Histomorphological studies of lungs at autopsy may reveal various diseases and their relative input towards death. DOI: 10.21276/APALM.2017.961References
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Tahir TM, Rehman F, Anwar S, Kamal F. Patterns of pulmonary morphological lesions seen at autopsy. Biomedica. 2013;29:64-8.
Pathak A, Mangal HM. Histopathology examination in medico-legal autopsy pros & cons. J Indian Acad Forensic Med. 2008;32(2):128-31.
Shweta, Deepti M, Vidhu M, Angmo P. Histopathological pattern in lung autopsy in Government medical college Jammu. Journal of Evolution of Medical and Dental Sciences. 2015;4(91):15694-96.
Bal MS, Sethi PS, Suri AK, Bodal VK, Kaur G. Histopathological pattern in lung autopsies. JPAFMAT. 2008;8(2):29-31.
Alexandre de MS, Aline DR, Mauro C, Edwin RP, Cecı´lia F, Vera LC. Demographic, etiological and histological pulmonary analysis of patients with acute respiratory failure: a study of 19 years of autopsies. Clinics. 2011;66(7):1193-197.
Chauhan G, Agrawal M, Thakkar N, Parghi B. Spectrum of histopathological lesions in lung autopsy. J Res Med Den Sci. 2015;3(2):109-12
Gross JS, Neufeld RR, Libow LS, Gerber I, Rodstein M. Autopsy study of the elderly institutionalized patient: Review of 234 autopsies. Arch Intern Med. 1998;148:173-6.
Ghosal R, Kloer P, Lewis KE. A review of novel biological tools used in screening for the early detection of lung cancer. Postgrad Med J. 2009;85:358-63.
Bora O, Celbis O, Onal R, Mizrak B, Karakoc Y. Multiple organ pathologies underlying in sudden natural deaths. Medicine Science. 2012;1(1):13-26.
Alexandre de MS, Edwin RP, Mauro C, Cecilia F, Vera LC. Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study. J Bras Pneumol.2008;34(2).
Niazi S. Morphological study of pulmonary embolism in autopsy cases. [Thesis]. Lahore: University of the Punjab, 1989.
Fang F, Lin FR, Li HZ. Clinicopathologic analysis of organizing pneumonia in elderly autopsies. Zhonghua Bing Li Xue Za Zhi Chinese Journl of Pathology. 2004;33(2):113-16.
Selvam V, Thamil SR , Subramaniam PM, Vijayanath V. Prevalence of Common Disease in Lungs and Liver; A Histopathological study. Journal of Pharmaceutical and Biomedical Sciences. 2011; 12: 1-5.
Garg M, Aggarwal AD, Singh S, Kataria SP. Tuberculous Lesions at Autopsy. J Indian Acad Forensic Med.2011; 33(2):116-19.
Tahir TM, Rehman F, Anwar S, Kamal F. Patterns of pulmonary morphological lesions seen at autopsy. Biomedica. 2013;29:64-8.
Pathak A, Mangal HM. Histopathology examination in medico-legal autopsy pros & cons. J Indian Acad Forensic Med. 2008;32(2):128-31.
Shweta, Deepti M, Vidhu M, Angmo P. Histopathological pattern in lung autopsy in Government medical college Jammu. Journal of Evolution of Medical and Dental Sciences. 2015;4(91):15694-96.
Bal MS, Sethi PS, Suri AK, Bodal VK, Kaur G. Histopathological pattern in lung autopsies. JPAFMAT. 2008;8(2):29-31.
Alexandre de MS, Aline DR, Mauro C, Edwin RP, Cecı´lia F, Vera LC. Demographic, etiological and histological pulmonary analysis of patients with acute respiratory failure: a study of 19 years of autopsies. Clinics. 2011;66(7):1193-197.
Chauhan G, Agrawal M, Thakkar N, Parghi B. Spectrum of histopathological lesions in lung autopsy. J Res Med Den Sci. 2015;3(2):109-12
Gross JS, Neufeld RR, Libow LS, Gerber I, Rodstein M. Autopsy study of the elderly institutionalized patient: Review of 234 autopsies. Arch Intern Med. 1998;148:173-6.
Ghosal R, Kloer P, Lewis KE. A review of novel biological tools used in screening for the early detection of lung cancer. Postgrad Med J. 2009;85:358-63.
Bora O, Celbis O, Onal R, Mizrak B, Karakoc Y. Multiple organ pathologies underlying in sudden natural deaths. Medicine Science. 2012;1(1):13-26.
Alexandre de MS, Edwin RP, Mauro C, Cecilia F, Vera LC. Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study. J Bras Pneumol.2008;34(2).
Niazi S. Morphological study of pulmonary embolism in autopsy cases. [Thesis]. Lahore: University of the Punjab, 1989.
Fang F, Lin FR, Li HZ. Clinicopathologic analysis of organizing pneumonia in elderly autopsies. Zhonghua Bing Li Xue Za Zhi Chinese Journl of Pathology. 2004;33(2):113-16.
Selvam V, Thamil SR , Subramaniam PM, Vijayanath V. Prevalence of Common Disease in Lungs and Liver; A Histopathological study. Journal of Pharmaceutical and Biomedical Sciences. 2011; 12: 1-5.
Garg M, Aggarwal AD, Singh S, Kataria SP. Tuberculous Lesions at Autopsy. J Indian Acad Forensic Med.2011; 33(2):116-19.
Published
2017-02-24
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