Superoxidised water: A promising disinfectant against bacterial and fungal pathogens

  • Munesh Kumar Gupta
  • Pradyot Prakash
  • Sujit Bharti
  • Anil Kumar Paswan
  • Dinesh Kumar Singh
  • Ragini Tilak
Keywords: Superoxidised water, Filamentous Fungi, Candida, Aspergillus, Pseudomonas

Abstract

Background: Disinfectants are frequently used in hospital settings as prophylaxis. Superoxidised water is one of them, which is claimed to have disinfectant property against different microbes. Aim:This study aims to assess the in vitro efficacy of different dilutions of superoxidised water against Candida spp. and filamentous fungi apart from several pathogenic bacterial isolates.Methods : The freshly grown clinical isolates of selected bacteria and fungi including Candida spp.,Aspergillus sp., Fusarium spp., Acremonium sp., Curvularia sp, and Bipolaris sp. were subcultured on culture plate with and without exposure of undiluted, five and ten times diluted, freshly generated superoxidised water.Results: There was complete inhibition of all bacteria and Candida species in undiluted as well as five and ten times diluted freshly generated superoxidised water whereas filamentous fungi used in the present study were inhibited only with the use of undiluted superoxidised water. Conclusion: Undiluted superoxidised water should be used to prevent the occurrence of molds infection as nosocomial pathogens. DOI: 10.21276/apalm.2017.982

References

1. Bonten MJ. Infection in the intensive care unit: prevention strategies. Curr Opin Infect Dis. 2002;15(4):401-5
2. Windmer AF, Frei R. Decontamination, disinfection and sterilization. In: Murray PR, Baron EJ, Landry ML, Jorgensen JH, Pfaller MA, editors. Manual of Clinical Microbiology, 9th ed. American Society for Microbiology Press, Washington. 2007.65-96
3. Bloomfield SF. Chlorine and iodine formulations. In: Ascenzi JM (Eds). Handbook of disinfectants and antiseptics. Marcel Dekker, Inc. New York. 1996. 133-158
4. Tanaka HY, Kaku HM, et al. Antimicrobial Antimicrobial activity of superoxidized water. J Hosp Infect. 1996; 34(1):43-9
5. Shetty NS, Holton SJ, Ridgway GL. Evaluation of microbicidal activity of a new disinfectant: Sterilox® 2500 against Clostridium difficile spores, Helicobacter pylori, vancomycin resistant Enterococcus species, Candida albicans and several Mycobacterium species. 1999. J Hosp Infect. 1999;41(2):101-5.
6. Choi TY, Yang EY. Bactericidal Effect of Medilox, an super oxidized water generated by Medilox against Bacteria, Fungi and Mycobacteria. Journal of Soonclumhvcing Medical Science 2009, 14(3):785–94.
7. Hedin G, Rynback J, Lore B. Reduction of bacterial surface contamination in the hospital environment by application of a new product with persistent effect. J Hosp Infect 2010; 75(2):112-5
8. McDonnell, G., Russell AD. Antiseptics and disinfectants: activity, action, and resistance. 1999. Clin Microbiol Rev. 1999; 12 (1):147-179
9. Bergstrom N, Bennett MA, Carlson CE, et al. Treatment of Pressure Ulcers. Clinical Practice Guideline # 15. Rockville, MD: U.S. Dept. Health and Human Services, Agency for Healthcare Policy and Research, 1994. AHCPR Pub 65-652.
10. Lindfors J. A comparison of an antimicrobial wound cleanser to normal saline in reduction of bioburden and its effect on wound healing. Ostomy Wound Manage. 2004; 50 (8):28-41.
11. Marais JT, Brözel VS. Electro-chemically activated water in dental unit water lines. Br Dent J. 1999;187(3):154-8
12. Selkon, JB, Babb JR, Morris R. Evaluation of the antimicrobial activity of a new super-oxidized water, Sterilox®, for the disinfection of endoscopes. J Hosp Infect 1999; 41(1) :59-70.
13. Rahal JJ. Antimicrobial resistance among and therapeutic options against gram-negative pathogens. Clin Infect Dis. 2009;49 (1):4–10
14. Park H, Hung YC, Kim C. Effectiveness of electrolysed water as a sanitizer for treating difference surfaces. J Food Prot 2002;65 (8):1276-80.
15. Kim C, Hung YC, Brackett RE. Roles of oxidation-reduction potential in electrolysed oxidizing and chemically modified water for the inactivation of food related pathogens. J Food Prot 2000; 63(1):19-24
16. Clark J. Barrett SP, Rogers M, Sapleton R. Efficacy of superoxidised water fogging in environmental decontamination. J Hosp Infect 2006;64(4):386-90
17. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB.Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004; 39 (3):309-17.
18. Fishman JA, Rubin RH: Infection in organ-transplant recipients. N Engl J Med. 1998;338(24):1741-51
19. Gunaydin M, Esen S, Karadag A, et al. In vitro antimicrobial activity of Medilox® superoxidised water. Ann Clin Microbiol Antimicrob 2014; 13: 29
Published
2017-02-03
Section
Original Article