Morphological characterization of Prostatic Ductal Carcinoma and impact on tumor grade

  • Faraz Ahmed Baig
  • Amna Hamid
  • Talat Mirza
  • Serajuddaula Syed
Keywords: Prostate, adenocarcinoma, ductal, Gleason score, Carcinoma


Objective: The clinical significance and impact of ductal prostatic carcinoma on overall tumor grade has been controversial. We therefore characterize the ductal and non-ductal subtypes of prostate adenocarcinoma and studied their impact on biological aggressiveness of tumor.Method: We utilized tumor bearing prostate biopsies reported during 2010-2014 from Dow Diagnostic Research & reference Laboratory to identify cases of Prostatic ductal and non-ductal acinar adenocarcinoma. Clinicopathologic variables of age and Gleason scores were analyzed and statistical analysis performed.Result: A total of 140 non-ductal acinar cases and 10 ductal cases were identified. Ductal cases were predominantly high grade with advanced histopathological features. (90%; p<0.03). There was no significant statistical difference with patient’s age.Conclusion: In the limited series of this histologic subtype, ductal cancers were more likely to present with advanced grade cancer, suggesting that timely detection of the disease is vital. 


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