Morphological characterization of Prostatic Ductal Carcinoma and impact on tumor grade
Keywords:
Prostate, adenocarcinoma, ductal, Gleason score, Carcinoma
Abstract
Objective: The clinical significance and impact of ductal prostatic carcinoma on overall tumor grade has been controversial. We therefore characterize the ductal and non-ductal subtypes of prostate adenocarcinoma and studied their impact on biological aggressiveness of tumor.Method: We utilized tumor bearing prostate biopsies reported during 2010-2014 from Dow Diagnostic Research & reference Laboratory to identify cases of Prostatic ductal and non-ductal acinar adenocarcinoma. Clinicopathologic variables of age and Gleason scores were analyzed and statistical analysis performed.Result: A total of 140 non-ductal acinar cases and 10 ductal cases were identified. Ductal cases were predominantly high grade with advanced histopathological features. (90%; p<0.03). There was no significant statistical difference with patient’s age.Conclusion: In the limited series of this histologic subtype, ductal cancers were more likely to present with advanced grade cancer, suggesting that timely detection of the disease is vital.References
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2. He Huang FC. Prostatic Ductal Adenocarcinoma Ex-hibits More Advanced Histopathological Features than Acinar Adenocarcinoma. North American Journal of Medicine and Science. 2012;Vol 5(4):208-11.
3. Morgan TM, Welty CJ, Vakar-Lopez F, Lin DW, Wright JL. Ductal adenocarcinoma of the prostate: in-creased mortality risk and decreased serum prostate specific antigen. The Journal of urology. 2010;184(6):2303-7. Epub 2010/10/19.
4. Epstein JI. Prostatic ductal adenocarcinoma: a mini review. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2010;19(1):82-5. Epub 2009/12/10.
5. Epstein JI, Allsbrook WC, Jr., Amin MB, Egevad LL. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. The American journal of surgical pathology. 2005;29:1228-42. Epub 2005/08/13.
6. Humphrey PA. Histological variants of prostatic car-cinoma and their significance. Histopathology. 2012;60:59-74. Epub 2012/01/04.
7. Grignon DJ. Unusual subtypes of prostate cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2004;17:316-27. Epub 2004/02/21.
8. Samaratunga H, Duffy D, Yaxley J, Delahunt B. Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic exten-sion. Human pathology. 2010;41:281-5.
9. Amin A, Epstein JI. Pathologic stage of prostatic ductal adenocarcinoma at radical prostatectomy: effect of percentage of the ductal component and associated grade of acinar adenocarcinoma. The American journal of surgical pathology. 2011;35(4):615-9.
10. Epstein JI, Woodruff JM. Adenocarcinoma of the prostate with endometrioid features. A light microscopic and immunohistochemical study of ten cases. Cancer. 1986;57(1):111-9. Epub 1986/01/01.
11. Bostwick DG, Kindrachuk RW, Rouse RV. Prostatic adenocarcinoma with endometrioid features. Clinical, pathologic, and ultrastructural findings. The American journal of surgical pathology. 1985;9(8):595-609. Epub 1985/08/01.
12. Greene LF, Farrow GM, Ravits JM, Tomera FM. Prostatic adenocarcinoma of ductal origin. The Journal of urology. 1979;121(3):303-5. Epub 1979/03/01.
13. Aydin H, Zhang J, Samaratunga H, Tan N, Magi-Galluzzi C, Klein E, et al. Ductal adenocarcinoma of the prostate diagnosed on transurethral biopsy or resection is not always indicative of aggressive disease: implications for clinical management. BJU international. 2010;105(4):476-80. Epub 2009/08/28
Published
2015-02-01
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