Correlation and Importance of Site in Mesenchymal Neoplasm - An Institutional Experience
Keywords:
Soft tissue, Sarcoma, site, histopathological type, Malignant
Abstract
Background: Soft tissue tumors are a complex group of neoplasms with differentiation towards mesenchymal tissue occurring in all age groups. These neoplasms can cause particular problems in their diagnosis. Detailed clinical information and biopsy is an essential component of the pre-operative diagnostic work up. Site of tumor is important in soft tissue tumors as site provides ancillary help in differential diagnosis for example three fourth soft tissue sarcomas are located in the extremities (most common in the thigh) and 10 % each in the trunk wall and retroperitoneum. Methods: This study comprised 200 cases. Soft tissue tumours were divided into benign and malignant categories, were further divided according to WHO classification and the site of occurrence and results were compared with some studies carried by other authors. Result: The most common site of soft tissue tumours as a whole is head and neck (n = 58; 29%) followed by upper limb, (n=51; 25.5%). Although benign tumours were seen to be maximum in head & neck, (n = 55; 27.5%) where as intermediate in upper limb (n=5; 2.5%) and malignant tumours showed a predilection for lower limb (n=10 cases; 5.0%) Conclusion: The current study was done to correlate the nature of lesions in case of soft tissues with respect to site and benign tumors were found to be more common amongst all with head and neck being frequently affected area. Sarcomas were more commonly found in lower limb and the results were compared with the studies done by other authors.References
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15. Hare HF, Cerny MJ. Soft Tissue Sarcoma. Cancer: 1963; 16:1132-7.
16. Jensen OM. A consecutive 7 year series of 1331 Benign Soft Tissue Tumours. Clinicopathologic Data. Comparison with sarcomas. Acta Orthopaedica. 1981: 52:287-93.
17. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG. A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg. 2005 Feb;102(2):246-55.
18. Shah H, Bhurgri Y, Pervez S. Malignant smooth muscle tumours of soft tissue – A demographic and clinicopathological study at a tertiary care hospital. J Pak Med Assoc. 2005; 55:1-4.
2. Fletcher CDM, Sundaram M, Rydholm A, Coindre JM, Singer. Soft Tissue Tumours: Epidemology, clinical features, histopathological typing and grading. In: Fletcher CDM, Unni KK, Mertens F, eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC 2002;12-18.
3. Fletcher CD, Martin-Bates E (1988). Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology 12:275-287.
4. Folpe AL, Morris RJ, Weiss SW (1999). Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. Mod Pathol 12: 894-902.
5. Makino Y. A clinicopathological study on Soft Tissue Tumours of the Head and Neck. Pathology International. 1979;29:389-408.
6. Kransdorf MJ. Benign Soft Tissue Tumours in a Large Referral Population: Distibution of specific diagnosis by age, sex and location. Am J Roentgenol. 1995; 164;395-402.
7. Shafar J, Behr G. Tumorous Abnormalities of Adipose tissue. Postgrad. Med. J. 1965; 41:15-7.
8. Mastrangelo G, Coindre J M, Ducimetiere F, Tos APD, Fadda E, Blay JY et al. Incidence of Soft Tissue Sarcoma and Beyond. Cancer 2012; 118:5339-48.
9. Ducimetiere F, Lurkin A, Vince DR, Decouvelaere MP, Istier L, Chalabreysse P et al. Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing. Ploss one. 2011; 6:1-14.
10. Trojani M, Contesso G, coindre .M, Rouesse J, Bui N.B, Mascarel A.D et al. Soft tissue sarcomas of adults: study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer. 1984; 33:37-42
11. Coindre JM, Terrier P, Guillou L, Doussal VL, Collin F, Fanchere D et al. Predictive value of Grade for metastasis development in the main histologic types of Adult Soft Tissue Sarcomas. A study of 1240 patients from the French Federation of cancer centres sarcoma group. Cancer. 2001; 91: 1914-26.
12. Talati N, Pervez S. Soft Tissue Sarcomas: Pattern Diagnosis or entity? J Pak Med Assoc. 1998; 48:272-5.
13. Enterline HT, Culberson JD, Rochlin DB, Brady LW. Liposarcoma, A Clinical and Pathological study of 53 cases. Cancer. 1960;13:932-50.
14. Sim FH, Pritchard DJ, Reimen HM, Edmonoson JH, Schray HM. Soft Tissue Sarcoma: Mayo Clinic Experience. Semin Surg Oncol. 1988;4:38-44.
15. Hare HF, Cerny MJ. Soft Tissue Sarcoma. Cancer: 1963; 16:1132-7.
16. Jensen OM. A consecutive 7 year series of 1331 Benign Soft Tissue Tumours. Clinicopathologic Data. Comparison with sarcomas. Acta Orthopaedica. 1981: 52:287-93.
17. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG. A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg. 2005 Feb;102(2):246-55.
18. Shah H, Bhurgri Y, Pervez S. Malignant smooth muscle tumours of soft tissue – A demographic and clinicopathological study at a tertiary care hospital. J Pak Med Assoc. 2005; 55:1-4.
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2018-09-20
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