Histopathological Study of Vesiculo-bullous Lesions of the Skin in Ajmer Region (Rajasthan)

  • Parmender Pachori Department of Pathology, Sawai Man Singh Medical College, Jaipur (Rajasthan)
  • Saroj Pachori Department of Pathology, Sawai Man Singh Medical College, Jaipur (Rajasthan)
  • Rohit Singh Jaggi 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
  • Geeta Pachori 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
  • Ravikant Sunaria 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
Keywords: Vesiculo-bullous lesions, H & E, pemphigus vulgaris, bullous pemphigoid


Background: Histopathology of skin biopsies is a useful technique in the investigation of various skin diseases out of which vesiculo-bullous lesions form one of the predominant groups. Methods: A histopathological study of vesiculo-bullous lesions of skin of 45 cases was carried out on skin biopsies received in Department of Pathology, Jawaharlal Nehru Medical College, Ajmer. The total number of skin biopsies received inclusive of vesiculo-bullous lesions was 828 over a period of two years. Among them the number of patients with vesiculo-bullous lesions was 45. Histologic examination of H & E-stained sections of the same were done. The level of split of lesions, mechanism of blistering and nature of infiltrate noted. Result: In the present study 45 cases of vesiculo-bullous lesions of the skin were diagnosed histopathologically. The commonest lesion overall was Pemphigus Vulgaris followed by Bullous Pemphigoid. Maximum number of cases were seen in age range of 41-50 years. Conclusion: Clinical examination along with histopathological examination of skin both together form an important diagnostic ancilliary technique in the management of patients with vesiculo-bullous lesions of skin where the immunofluorescence technique is not available.


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