Histopathological Study of Vesiculo-bullous Lesions of the Skin in Ajmer Region (Rajasthan)

  • Parmender Pachori Department of Pathology, Sawai Man Singh Medical College, Jaipur (Rajasthan)
  • Saroj Pachori Department of Pathology, Sawai Man Singh Medical College, Jaipur (Rajasthan)
  • Rohit Singh Jaggi 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
  • Geeta Pachori 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
  • Ravikant Sunaria 2Department of Pathology, Jawaharlal Nehru Medical College, Ajmer (Rajasthan)
Keywords: Vesiculo-bullous lesions, H & E, pemphigus vulgaris, bullous pemphigoid

Abstract

Background: Histopathology of skin biopsies is a useful technique in the investigation of various skin diseases out of which vesiculo-bullous lesions form one of the predominant groups. Methods: A histopathological study of vesiculo-bullous lesions of skin of 45 cases was carried out on skin biopsies received in Department of Pathology, Jawaharlal Nehru Medical College, Ajmer. The total number of skin biopsies received inclusive of vesiculo-bullous lesions was 828 over a period of two years. Among them the number of patients with vesiculo-bullous lesions was 45. Histologic examination of H & E-stained sections of the same were done. The level of split of lesions, mechanism of blistering and nature of infiltrate noted. Result: In the present study 45 cases of vesiculo-bullous lesions of the skin were diagnosed histopathologically. The commonest lesion overall was Pemphigus Vulgaris followed by Bullous Pemphigoid. Maximum number of cases were seen in age range of 41-50 years. Conclusion: Clinical examination along with histopathological examination of skin both together form an important diagnostic ancilliary technique in the management of patients with vesiculo-bullous lesions of skin where the immunofluorescence technique is not available.

References

Cotran RS, Kumar V , Robbins SL. Robbins and Cotran’s Pathologic basis of Disease. 8th ed. Philadelphia: Saunders Elsevier; 2010. p112-28.

Chan PT. Clinical features and diagnosis of common Autoimmune Bullous Diseases in Hong Kong: Medical Bulletin (Hong Kong Medical Diary) 2008;13:10

Zeber TJ. Punch Biopsy of the skin. American Fam Physician 2002:65(6):1155-1158.

Wu H , Schapiro B , Harrist TJ. Noninfectious vesiculobullous and vesiculopustular diseases. In: Elder D, Elenitsas R, Johnson BL , Murphy GF, ed. Lever’s histopathology of the skin , 9th edition. Philadelphia: LippincottWilliams and Wilkins. 2005: 243-91.

Sanjeev Narang, Ravi Jain: An evaluation of Histopathological findings of skin Biopsies in various skin disorders.Annals of Pathology and Laboratory Medicine,2015,2(01):42-46

Sandhya Panjeta Gulia , Swati Anil Wadhai , Lavanya M, Roshni Menon, Madhusudhan Chaudhary, SP Arun Kumar: Histopathological Pattern of Skin Diseases in a Teaching Hospital Puducherry. International Journal of Recent Trends in Science and Technology,2014;1(1):45-50

Najla M. Alghanmi, Layla S. Abdulla;Pathology of skin diseases. Saud Med J 2013; 34(1)74-79

Kabir AK, Kamal M, Choudhury AM. Clinicopathological correlation of blistering diseases of skin .Bangladesh Med Res Counc Bull 2008;34:48-53.

Prashant R Patel , Priti B Patel , SG Chiplonkar . Histopathological study of vesiculobullous lesions of the skin: A study at Tertiary Care Hospital. 2014

Leena JB, Chandrashekhar M, Vijaya B, Sunila R, and Manjunath GV. A Clinicopathological study of immunobullous lesions of the skin . Advance Laboratory Medicine International 2012;2:49-60.

Handa F., Agarwal RR, Garg RK. A clinical study of 85 cases of pemphigus. Indian J Dermatol Venereol. 1973;39:106-11.

Arundhati S, Ragunatha S , Mahadeva KC. A Cross-Sectional study of Clinical, Histopathological and Direct Immunoflorescence Spectrum of Vesiculobullous Disorders . J ClinDiagn Res2013;7:2788-92.

Khan WA , Valand AG. Pattern of non-infectious vesiculous and vesiculopustular skin disease in a large tertiary care hospital . Bombay Hospital Journal 2010;52:172-6.

Pisanti S, Sharav Y, Kaufman E , Posner LN . Pemphigus vulgaris: incidence in Jews of different ethnic groups, according to age, sex and initial lesions. Oral Surg Oral Med Oral Pathol.1974;38(3)382-87.

Shafi M, Khatri ML, Mashina M , Ben –Ghazeil M. Pemphigus A clinical study of of 109 cases from Tripoli , Libya . Indian J Dermatol Venereol Leprol. 1994;60:140-43

Published
2021-06-29
Section
Original Article