Histomorphological Spectrum of Cholecystectomy Specimen and Incidence of Unexpected Primary Carcinoma Gall Bladder- Review of Cholecystectomy Specimens from A North Indian Hospital

  • Aruna Chhikara
  • B. S. Johal
Keywords: Cholecystitis, Cholelithiasis, Unexpected Primary Gall bladder carcinoma, histomorphology


Background: Cholecystectomy is one of the most commonly performed surgery in the world. Cholelithiasis is the most common indication for elective cholecystectomy. The incidence of Unexpected primary carcinoma gall bladder varies from 0.23 to 1.9%.   Method: Histomorphological spectrum in 367 cholecystectomy spectrum was studied retrospectively.   Results: There was a preponderance of females, with male to female ratio of 1: 2.4. The mean age of the cases was 49.9 years. Most of the cases were in 4th and 5th decades of life. Chronic cholecystitis was the most common histological findings seen in 91% cases. Associated cholelithiasis was present in 219/367 cases. Other lesions observed were acute cholecystitis (3.8%), acute on chronic cholecystitis (1%), adenomyomatosis (0.5%) follicular cholecystitis (0.5%) and xanthogranulomatous cholecystitis (0.5%). Dysplasia was seen in 0.3% cases. Eleven cases of adenocarcinoma were notices, two including Unexpected primary gall bladder carcinoma.   Conclusion: Cholecystectomy specimens show varied histomorphological spectrum. Gross examination of the specimen does not rule out underlying premalignant or malignant condition. A keen histopathological examination of all cholecystectomy specimens must be done.

Author Biographies

Aruna Chhikara
Department of Laboratory Sciences, Johal Multispeciality Hospital, Hoshiarpur Road, Rama Mandi, Jalandhar, Punjab 144005
B. S. Johal
Johal Multispeciality Hospital, Jalandhar, Punjab-144005


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Original Article