Seroprevalence and Trends in Transfusion Transmitted Infections Among Blood Donors
Keywords:
Sero-prevalence, Voluntary donors, Replacement donors, Blood Bank, TTI
Abstract
Introduction: Timely transfusion of blood saves millions of lives, but unsafe transfusion practices put millions of people at risk of transfusion transmitted infections (TTIs).There are several infectious as well as non-infectious risks associated with transfusion of blood. With every unit of blood transfused, there is 1%chance of transfusion associated problems including transfusion transmitted infections. In India blood is screened for five diseases which could be transmitted through blood and produce serious illness- HIV, Hepatitis B, Hepatitis C, Syphilis and Malaria.Aims and objectives :(1) To assess the trend of transfusion transmitted infections (TTIs)among blood donors from the records (2011-2013) at blood bank, GCSMCH, Ahmedabad, Gujarat. (2) To study the sero-prevalence of TTIs among blood donors from the records.Methods: A record based study was conducted from June 2011- December 2013. Data were collected from the records of blood bank. Data regarding sex, screening test results and type of donors were collected from the records.Results: Out of 2178 donors, voluntary donors were (4.17%) in comparison to replacement donors (95.83%). Amongst blood donors, prevalence of HBV (0.73%), HCV (0.09%), HIV (0.09%) and Syphilis (1.65%) were noted.Conclusion: TTIs were more prevalent in replacement donors than voluntary donors. The number of voluntary donors has risen from 2011 -2013, but there is male preponderance in both voluntary and replacement donors than females.References
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17. Pattanshetty A, Kulkarni K, Baragundi M. Seroprevalence of Co-Infections Among Blood Donors in A Blood Bank of A Tertiary Health Care Centre. Annals Of Pathology And Laboratory Medicine, 2016:3(1):A29-32.
18. Pahuja S, Sharma M, Baitha B, Jain M. Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and human immunodeficiency virus in Delhi blood donors. A hospital based study. Jpn J InfDis. 2007; 60:389–391.
19. Chandra T, Kumar A, Gupta A. Prevalence of transfusion transmitted infections in blood donors: an Indian experience. TropDoct. 2009; 39:152–154. doi: 10.1258/td.2008.080330
20. Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J PatholMicrobiol. 2010; 53:308–309.
21. Bhattacharya P, Chakraborty S, Basu SK. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004–2005. Exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007; 13:3730–3733.
22. Shah N, Shah JM, Jhaveri P, Patel K, Shah CK, Shah NR. Seroprevalence of HBV, HCV, HIV and syphilis among blood donors at a tertiary Care Teaching Hospital in Western India. Gujarat Medical Journal.2013; 68(2): 35-39.
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2. .Gupta PK, Kumar H, Basannar DR, Jaiprakash M. Transfusion transmitted infections in armed forces: prevalence and trends. MJAFI. 2006; 62:348-350.
3. WHO factsheet on Blood Safety and Donation, 2008
4. WHO guidelines of Blood Transfusion Safety Aappia, CH-1211 Geneva 27,Switzerland
5. Government of India. Drugs and Cosmetics Rules, 1945 (Amended till 30th Jun’05) available at http://www.cdsco.nic.in/html-drugsandcosmeticsact.pdf
6. National Blood Policy produced and published by NACO (National AIDS Control Organization), Ministry of Health and Family Welfare, Govt of India, New Delhi.Jun’03 (Reprint2007)
7. Khan ZT, Asim S, Tariq Z, Ehsan MA, Malik RA, Ashfaq B, Hayat: Prevalence of transfusion transmitted infectious in healthy blood donors in Rawalpindi District, Pakistan: a five year survey. Inter J of Pathology. 2007; 5(1): 21-25.
8. WHO: The cinical use of blood in medicine,obstetrics ,paediatrics, surgery and anaesthesia , transfusion and burns, Geneva, Switzerland ; 2001.
9. Giri PA, Deshpande JD, Phalke DB, Karle LB: Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India: J. Fam. Med. Primary Care .2012; 1: 48-51.
10. Kakkar N, Kaur R, Dhanoa J. Voluntary donors – need for a second look. Indian J PatholMicrobiol. 2004; 47:381-383.
11. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indial J PatholMicrobiol. 2001; 44:409-412.
12. Sing B, Verma M, Verma K. Markers for transfusion associated hepatitis in north Indian blood donors: prevalence and trends. Jpn J Infect dis. 2004; 57:49-51.
13. Asif N, Kokhar N, Ilahi F. Seroprevalence of HBC, HCV and HIV infection among voluntary non-remunerated and replacement donors in northern Pakistan. Pak J Med Sci. 2004; 1:24-28.
14. Matee MIN, Magesa PM, Lyamuya EF. Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis infections among blood donors at the Muhimbili National Hospital in Dar Es Salaam, Tanzania. BMC Public Health. 2006; 6:21. Doi: 10.1186/1471-2458-6-21.
15. Pattanshetty A, Kulkarni K, Baragundi M. Seroreactivity of Syphilis Among Blood Donors of A Blood Bank. Annals Of Pathology And Laboratory Medicine, 2016:3(1), A41-44.
16. P.Pallavi, C.K. Ganesh and et al. Seroprevalence and Trends in Trends in Transfusion Transmitted Infections among Blood Donors in University Hospital Blood Bank: A 5 Year Study. Indian J Hematol Blood Transfus. 2011; 27(1):1-6.
17. Pattanshetty A, Kulkarni K, Baragundi M. Seroprevalence of Co-Infections Among Blood Donors in A Blood Bank of A Tertiary Health Care Centre. Annals Of Pathology And Laboratory Medicine, 2016:3(1):A29-32.
18. Pahuja S, Sharma M, Baitha B, Jain M. Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and human immunodeficiency virus in Delhi blood donors. A hospital based study. Jpn J InfDis. 2007; 60:389–391.
19. Chandra T, Kumar A, Gupta A. Prevalence of transfusion transmitted infections in blood donors: an Indian experience. TropDoct. 2009; 39:152–154. doi: 10.1258/td.2008.080330
20. Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J PatholMicrobiol. 2010; 53:308–309.
21. Bhattacharya P, Chakraborty S, Basu SK. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004–2005. Exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007; 13:3730–3733.
22. Shah N, Shah JM, Jhaveri P, Patel K, Shah CK, Shah NR. Seroprevalence of HBV, HCV, HIV and syphilis among blood donors at a tertiary Care Teaching Hospital in Western India. Gujarat Medical Journal.2013; 68(2): 35-39.
23. Sundaram S, Karir S, Haider S, Singh S.B, Kiran A. sero-prevalence of transfusion transmitted infections among blood donors at blood bank of Rajendra Institute of Medical Sciences, Ranchi. Healthline journal.2015; 6(1);36-40.
Published
2016-08-23
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