Association between the bone turnover markers and the gynecologic factors among Moroccan women

Basma Nejjar; Abdellatif Bour; Anis Sfendla; Adil Najdi; Olivier Bruyère; Etienne Cavalier

Basma Nejjar Faculty of medicine, Universty of Liege Belgium and Faculty of sciences, University Ibn Tofail Morocco
Abdellatif Bour Department of Biology, Team of Food and Nutritional Transition (ETAN), Laboratory of Biological assays, Faculty of Sciences, University Ibn Tofail, 14000 Kenitra, Morocco
Anis Sfendla
Adil Najdi
Olivier Bruyère
Etienne Cavalier

Keywords: Bone turnover, markers, Gynecologic, Women, Morocco.

Abstract

Background: The action of bone cells on the bone mineral density can be highlighted from their enzymatic activities, by the bone alkaline phosphates (BAP) and the Cross Laps-telopeptide terminal of the collagen type 1 (β-CTX). They are reliable to explore the activity of bone turnover. We aim to put in perspective the association between gynecological factors and the concentration of bone turnover markers (BTMs) among Moroccan women.Methods: This is a cross-sectional study of 125 women from February to April 2015. A randomized sample was made. The biochemical parameters of bone metabolism concerned serum calcium, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), phosphorus , BAP and β-CTX. All data related to gynecologic, sociodemographic and anamnesis parameters was collected by standardized questionnaire.Result: Among 125 women, 64(51.42) were menopausal, the mean BAP was 22.1±7.6 ng/L, the median of the interval between successive births “IBSB” and of β-CTX were 36.0[24.0-58.0] months, 368.5 [237.0-504.8]ng/L. A positive correlation was observed between the β-CTX and IBSB (r=0.2,p=0.05). The BAP concentration was higher in menopausal women (p<0.001). The linear regression showed that 12% of BAP concentration was associated to the menopause (R2=0.12, p=0.001) but no associated factors was founded with concentration of β-CTX.Conclusion: Our study shows that the menopause is associated factor with concentration of BAP and IBSB is correlated with the concentration of β-CTX. DOI: 10.21276/AABS.2017.1248

Author Biography

Basma Nejjar, Faculty of medicine, Universty of Liege Belgium and Faculty of sciences, University Ibn Tofail Morocco

Department of Clinical Chemistry, Unilab Lg-CIRM, Faculty of Medicine, University of Liège, CHU Sart-Tilman, 4000 Liege, Belgium &Department of Biology, Team of Food and Nutritional Transition (ETAN), Laboratory of Biological assays, Faculty of Sciences, University Ibn Tofail, 14000 Kenitra, Morocco

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