Does Interleukin 22 have a role in periodontal pathogenesis? A short Review
Keywords:
IL-22, periodontitis, host defence, inflammation
Abstract
Many studies from recent years have shown that Interleukin 22 (IL-22) plays a major role in both the defence against certain microbes and the development and maintenance of chronic inflammatory diseases. Periodontal disease, including gingivitis and periodontitis, is caused by the interaction between pathogenic bacteria and the host immune system. Further animal and human studies are needed to investigate the role of IL-22 in periodontal health and disease. DOI: 10.21276/AABS.2017.1328References
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15. Rutz S, Eidenschenk C, Ouyang W. IL-22, not simply a Th17 cytokine. Immunol Rev. 2013 Mar;252(1):116-32.
16. Liang SC, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006;203:2271–2279.
17. Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004;21:241–254.
18. Wolk K, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006;36:1309–1323.
19. Liang SC, et al. IL-22 Induces an Acute-Phase Response. J Immunol 2010;185:5531–5538.
20. Aujla S, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008;14:275–281.
21. Ki S-H, et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 2010;52:1291–1300.
22. Kong X, et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 2012;56:1150–1159.
23. Dudakov JA, et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 2012;336:91–95.
24. Savan R, et al. A novel role for IL-22R1 as a driver of inflammation. Blood 2011;117:575–584.
25. Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med 2010;207:1293– 1305.
2. Dumoutier, L., Louahed, J., and Renauld, J.C. (2000a). Cloning and characterization of IL-10-related T cell-derived inducible factor (IL- TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. 164, 1814–1819.
3. Wolk, K., Kunz, S., Asadullah, K., and Sabat, R. (2002). Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol. 168, 5397–5402.
4. Dumoutier L, Van Roost E, Colau D, Renauld JC. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte- stimulating factor. Proc Natl Acad Sci USA 2000;97:10144–10149.
5. Xie MH, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem 2000;275:31335–31339.
6. Zenewicz LA1, Flavell RA. Recent advances in IL-22 biology. Int Immunol. 2011 Mar;23(3):159-63.
7. Sonnenberg, G. F., Fouser, L. A. & Artis, D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 2011. 12, 383–390.
8. Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14, 275–281 (2008).
9. Zenewicz, L. A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647–659 (2007).
10. Hanash, A. M. et al. Interleukin-22 protects intestinal stem cells from immune- mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 37, 339–350 (2012).
11. Dudakov, J. A. et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 336, 91–95 (2012).
12. Zheng, Y. et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648–651 (2007).
13. Sherlock, J. P. et al. IL-23 induces spondyloarthropathy by acting on ROR-gammat þ CD3 þ CD4-CD8- entheseal resident T cells. Nat. Med. 18, 1069–1076 (2012).
14. Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259–263 (2012).
15. Rutz S, Eidenschenk C, Ouyang W. IL-22, not simply a Th17 cytokine. Immunol Rev. 2013 Mar;252(1):116-32.
16. Liang SC, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006;203:2271–2279.
17. Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004;21:241–254.
18. Wolk K, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006;36:1309–1323.
19. Liang SC, et al. IL-22 Induces an Acute-Phase Response. J Immunol 2010;185:5531–5538.
20. Aujla S, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 2008;14:275–281.
21. Ki S-H, et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 2010;52:1291–1300.
22. Kong X, et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 2012;56:1150–1159.
23. Dudakov JA, et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 2012;336:91–95.
24. Savan R, et al. A novel role for IL-22R1 as a driver of inflammation. Blood 2011;117:575–584.
25. Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med 2010;207:1293– 1305.
Published
2017-02-21
Issue
Section
Review Articles
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