Role of bone marrow biopsy in myeloproliferative neoplasm: study of 49 cases
Keywords:
Chronic myeloid leukemia, bloody tap, bone marrow biopsy, smear imprint
Abstract
The aim of the current study was to analyze the value of bone marrow biopsy and imprint smears in myeloproliferative neoplasm. Chronic myeloid leukemia is the most common leukemia amongst MPN as well as all acute and chronic adult leukemia. Diagnosis can be made on peripheral blood, bone marrow examination and molecular pathology findings. But in some cases bone marrow plays a very valuable role in the diagnosis. In the present study, bone marrow biopsies were re-examined in 49 patients with MPN. And it was found that BMB helped in 10 cases of MPN for making final diagnosis.DOI: 10.21276/AABS.1603References
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2. Bhutani M, Vora A, Kumar L, Kochupillai V. Lympho-hemopoietic malignancies in India. Med Oncol 2002;19:141-50.
3. Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 1960;25:85-109.
4. Sokal JE, Baccarani M, Tura S, et al. Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation. Blood 1985;66:1352–7.
5. Kaur M, Singh APS, Kapoor SH, Puri A. Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice Journal of Clinical and Diagnostic Research. 2014 Aug, Vol-8(8): FC13-FC16
6. Lee SJ. Chronic myelogenous leukemia. Br J Haematol. 2000;111:993–1009.
7. Riley RS, Hogan TF, Pavot DR, Forysthe R, Massey D, Smith E, et al. A pathologist’s perspective on bone marrow aspiration and biopsy; Performing a bone marrow examination. J Clin Lab Anal. 2004;18(2):70–9.
8. Islam A. Bone marrow aspiration prior to bone marrow core biopsy using the same bone marrow biopsy needle. A good or bad practice. J Clin Pathol. 2007;60:212–15.
9. Humphries JE. Dry tap bone marrow aspiration: clinical significance. Am J Hematol. 1990;35(4):247-50.
10. Yookarin KH, Basu D, Dutta DK. Bone marrow trephine biopsy findings in chronic myeloid leukemia. Malaysian Journal of pathology. 2002;24:37-43.
11. Younus U, Saba K, Aijaz J, Bukhari MH, Naeem S. Significance of Bone Marrow Histology in the Diagnosis of Acute Myeloid Leukemia. ANNALS. 2011;17(1):5-8.
12. Tilak V, Das S, Bundhun S. Value of Bone Marrow Imprint Smears in Early Diagnosis Of Bone Marrow Pathologies. J Clin Diagn Res. 2014 Nov; 8(11): FC01–FC03.
13. Steven J, Jubelirer. The role of the bone marrow examination in the diagnosis of immune thrombocytopenic purpura: case Series and Literature Review. Clinical and Applied Thrombosis/Hemostasis. 2002;8:173-76.
14. Miranda MB, Lauseker M, Kraus MP, Proetel U, Hanfstein, Fabarius A et al. Secondary malignancies in chronic myeloid leukemia patients after imatinib-based treatment: long-term observation in CML Study IV. Leukemia 2016 Jun; 30(6): 1255–1262.
Published
2017-08-18
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