Selective IgM deficiency presenting as chronic diarrhea: A case report
Keywords:
IgM, Primary immunodeficiency, Diarrhea, Celiac disease
Abstract
Primary immunodeficiency (PID) is a heterogeneous disorder resulting from reduced or absent function of one of the components of immune system like T-cells, B-cells, NK cells, neutrophils, its receptor, immunoglobulins, complements and genes responsible for rearrangement of T- cell receptor and immunoglobulin and its signaling molecule. Among the clinical manifestation sinusitis, pneumonia, bronchiectasis, allergic disease, autoimmune disease and diarrhea are common manifestation in Antibodies deficiency.A 4-years-old boy presented with chronic diarrhea and failure to grow. On endoscopy, there was nodule in D2 region which, on histopathological examination showed features mimicking as celiac disease. His serum anti-TTg Ab was within normal limits and serum Ig M was deficient.References
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3. Lai Ping So A, Mayer L. Gastrointestinal manifestations of primaryimmunodeficiency disorders. Semin Gastrointest Dis. 1997 Jan; 8(1):22-32. Review. Pub Med PMID: 9000499.
4. Botto M, Kirschfink M, Macor P, Pickering MC, Würzner R, Tedesco F. Complement in human diseases: Lessons from complement deficiencies. Mol Immunol. 2009 Sep;46(14):2774-83. doi:10.1016/j.molimm.2009.04.029. E pub 2009 May 28 Review. Pub Med PMID: 19481265.
5. Hosseni A H, Mesdaghi M, Sayyari A K, Chavoshzadeh Z: Chronic diarrhea as a presenting manifestation of common variable Immunodeficiency, Archives of Pediatric Infectious disease 2013; 1(h) 180-182
6. Kirkpatrick P, Riminton S. Primary immunodeficiency diseases in Australia and New Zealand. J Clin Immunol. 2007 Sep; 27(5):517-24. Epub 2007 Jun 22. Pub Med PMID: 17588141.
7. McCusker C, Warrington R. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1:S11. doi: 10.1186/1710-1492-7-S1-S11. Pub Med PMID: 22165913; Pub Med Central PMCID: PMC3245434.
Published
2015-06-26
Issue
Section
Case Reports
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