Angiomatoid Fibrous Histiocytoma: Can it be diagnosed in uncommon locations on morphological features?

  • Neeraj Dhameja
  • A Kunwar
  • Vikash Prasad Institue of Medical Sciences ,BHU,
  • S C Goel
Keywords: Angiomatoid Fibrous Histiocytoma, Pseudoangiomatoid Spaces, Immunohistochemistry


Angiomatoid Fibrous Histiocytoma is an uncommon soft tissue tumor of uncertain histogenesis with peak incidence in younger age group. The extremeties are the commonest site though rarely it has been described in various other locations including bone. It shows certain unique histopathological and molecular features and has an indolent behaviour with recurrence in some cases and very rarely metastasis.

Author Biography

Vikash Prasad, Institue of Medical Sciences ,BHU,
MD Pathology 3rd year


1. Enzinger FM. Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer 1979;44:2147-57.

2. Smith JCF, Cin PD. Angiomatoid fibrous histiocytoma. In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon:IARC Press;2002.p194-5..

3. Costa MJ, Weiss S. Angiomatoid Malignant Fibrous Histiocytoma: A Follow-up Study of 108 Cases with Evaluation of Possible Histologic Predictors of Outcome. Am J Surg Pathol 1990;14:1126-32.

4. Chen G, Folpe AL, Colby TV, Sittampalam K, Patey M, Chen MG, et al. Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Modern Pathology 2011;24:1560-70.

5. Kao Y-C, Lan J, Tai H-C, Li C-F, Liu K-W, Tsai J-W, et al. Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology. J Clin Pathol 2014;67:210-15.

6. Thway K. Angiomatoid Fibrous Histiocytoma A Review With Recent Genetic Findings. Arch Pathol Lab Med.2008;132:273-77.

7. Inwards CY, Oliveira AM. Tumors of the osteoarticular system. In: Fletcher CDM, editor. Diagnostic Histopathology of Tumors.4thed. Philadelphia: Elsevier-Saunders; 2013.p1871-1932.

8. Petrey WB, LeGallo RD, Fox MG, Gaskin CM. Imaging characteristics of angiomatoid fibrous histiocytoma of bone. Skeletal Radiol.2011;40:233-37.

9. Mangham DC, Williams A, Lalam RK, Brundler M-A, Leahy MG, Cool WP. Angiomatoid Fibrous Hitiocytoma of Bone: A Calcifying Sclerosing Variant Mimicking Osteosarcoma. Am J Surg Pathol 2010;34:279-85.
Case Reports