Compare the safety and efficacy of loteprendol etabonate 0.5% and prednisolone acetate 1% in the post operative inflammation following cataract extraction with intra ocular lens (IOL) implant

  • Rajwinder Kaur Gian Sagar Medical College and Hospital, Banur, Rajpura
  • Prithpal S Matreja
  • Balbir Khan
  • R N Bhatnagar
Keywords: Inflammation, steroids, intraocular pressure, loteprednol, prednisolone


Background: Inflammatory conditions represent one of the most common encountered clinical challenges in the ophthalmology. Topical steroids remain the cornerstone of ocular therapy. Loteprednol etabonate is a site-specific agent, approximates the efficacy of prednisolone acetate and has minimal effect on intraocular pressure (IOP). Limited studies have compared these two drugs, hence, it was considered worthwhile to compare loteprendol etabonate and prednisolone acetate in post operative inflammation following cataract extraction with IOL implant.Methodology: 30 patients operated for cataract extraction surgery with IOL implantation were studied for post operative inflammation and IOP changes, were divided into two groups. Group A received loteprednol etabonate and group B received prednisolone acetate. Cells in the anterior chamber (AC),  flare were graded Signs of post operative inflammation including cells in anterior chamber (AC) and flare score were observed on day 1, 3, 8, 15 and 30. IOP was measured in each of these visits.Results: Both loteprdnol and prednisolone were equally efficacious in decreasing AC cells and flare but there was a statistically significant difference in the increase of IOP caused by both drugs. IOP increase of ≥10mm Hg was observed in patients receiving prednisolone. Conclusion: Both drugs were found to be highly effective in controlling post cataract extract inflammation with favourable safety profile.  Loteprednol etabonate was found to have lesser propensity as compared to prednisolone acetate to increase IOP.

Author Biography

Rajwinder Kaur, Gian Sagar Medical College and Hospital, Banur, Rajpura
Assistant professorDepartment of opthalmology 


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Original Article