Primary Synovial Sarcoma Kidney: A Rare Case Report
Keywords:
Primary Synovial Sarcoma, Kidney, Microscopy, IHC, Cytogenetics
Abstract
Primary synovial sarcoma (PSS) of the kidney is a rare entity. Since morphologic differentiation from other tumors like metastatic sarcoma, sarcomatoid renal cell carcinoma, retroperitoneal liposarcoma may be difficult, other diagnostic modalities like immunohistochemistry, cytogenetic & advanced molecular analyses need to be employed.Despite its rarity & non specific presentation, pathologist and clinicians should consider synovial sarcoma in the differential diagnosis of renal masses for the proper management of patients, especially when histopathological examination shows malignant spindle cell neoplasm of kidney.References
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3. G. M. Farrow, E. G.Harrison Jr., D. C. Utz, andW.H. ReMine, “Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. I,” Cancer, 1968;22:545–550.
4. T. Tsukamoto and M. M. Lieber, “Sarcomas of the kidney, urinary bladder, prostate, spermatic cord, paratestis and testis in adults,” in Soft Tissue Sar-comas: Diagnosis and Treatment, J. H. Raaf, Ed., Mosby Yearbook, St. Louis, Mo, USA, 1992.
5. Dassi V, Das K, Singh BP, Swain SK. Primary synovial sarcoma of kidney: A rare tumour with an atypical presentation. Indian J Urol. 2009;25:269–71.
6. Schaal CH, Navarro FC, Francisco A, Neto M. Pri-mary renal sarcoma with morphologic and immu-nohistochemical aspects compatible with synovial sarcoma. Int Braz J Urol.2004;30:210–3.
7. Mauricio A, Paláu L, Pham TT, Barnard N, Merino MJ. Primary synovial sarcoma of the kidney with rhabdoid features. Int J Surg Pathol. 2007;15:421–8.
8. Divetia M, Karpate A, Basak R, Desai SB. Synovial sarcoma of the kidney. Ann Diagn Pathol. 2008;12:333–9.
9. Tornkvist M, Wejde J, Ahlen J, Brodin B, Larsson O. A novel case of synovial sarcoma of the kidney: Impact of SS18/SSX analysis of renal hemangiope-ricytoma-like tumours. Diagn Mol Pathol. 2004;11:47–51.
10. Wang ZH, Wang XC, Xue M. Clinicopathologic analysis of 4 cases of primary renal synovial sarco-ma.Chin J Cancer. 2010, 29 (2): 212-6.
11. Smith S, Reeves BR, Wong L, Fisher C. A consistent chromosome translocation in synovial sarcoma. Cancer Genet Cytogenet. 1987, 26 (1): 179-80.
12. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sar-coma: A multi-institutional retrospective study of 243 patients. Cancer Res. 2002, 62 (1): 135-40.
13. Nilsson G, Skytting B, Xie Y, Brodin B, Perfekt R, Mandahl N, et al. The SYT-SSX1 variant of syn-ovial sarcoma is associated with a high rate of tu-mor cell proliferation and poor clinical outcome. Cancer Res, 1999, 59: 3180-4.
14. Kawahara T, Sekiguchi Z, Makiyama K, Nakayama T, Nagashima Y, Kita K, et al. Primary synovial sarcoma of the kidney. Case Rep Oncol. 2009;2:189–93.
2. V. T. DeVita Jr., S. Helman, and S. A. Rosenberg, Cancer: Principles & Practice of Oncology, Lippin-cott Williams & Wilkins, Philadelphia, Pa, USA, 6th edition, 2001.
3. G. M. Farrow, E. G.Harrison Jr., D. C. Utz, andW.H. ReMine, “Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. I,” Cancer, 1968;22:545–550.
4. T. Tsukamoto and M. M. Lieber, “Sarcomas of the kidney, urinary bladder, prostate, spermatic cord, paratestis and testis in adults,” in Soft Tissue Sar-comas: Diagnosis and Treatment, J. H. Raaf, Ed., Mosby Yearbook, St. Louis, Mo, USA, 1992.
5. Dassi V, Das K, Singh BP, Swain SK. Primary synovial sarcoma of kidney: A rare tumour with an atypical presentation. Indian J Urol. 2009;25:269–71.
6. Schaal CH, Navarro FC, Francisco A, Neto M. Pri-mary renal sarcoma with morphologic and immu-nohistochemical aspects compatible with synovial sarcoma. Int Braz J Urol.2004;30:210–3.
7. Mauricio A, Paláu L, Pham TT, Barnard N, Merino MJ. Primary synovial sarcoma of the kidney with rhabdoid features. Int J Surg Pathol. 2007;15:421–8.
8. Divetia M, Karpate A, Basak R, Desai SB. Synovial sarcoma of the kidney. Ann Diagn Pathol. 2008;12:333–9.
9. Tornkvist M, Wejde J, Ahlen J, Brodin B, Larsson O. A novel case of synovial sarcoma of the kidney: Impact of SS18/SSX analysis of renal hemangiope-ricytoma-like tumours. Diagn Mol Pathol. 2004;11:47–51.
10. Wang ZH, Wang XC, Xue M. Clinicopathologic analysis of 4 cases of primary renal synovial sarco-ma.Chin J Cancer. 2010, 29 (2): 212-6.
11. Smith S, Reeves BR, Wong L, Fisher C. A consistent chromosome translocation in synovial sarcoma. Cancer Genet Cytogenet. 1987, 26 (1): 179-80.
12. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sar-coma: A multi-institutional retrospective study of 243 patients. Cancer Res. 2002, 62 (1): 135-40.
13. Nilsson G, Skytting B, Xie Y, Brodin B, Perfekt R, Mandahl N, et al. The SYT-SSX1 variant of syn-ovial sarcoma is associated with a high rate of tu-mor cell proliferation and poor clinical outcome. Cancer Res, 1999, 59: 3180-4.
14. Kawahara T, Sekiguchi Z, Makiyama K, Nakayama T, Nagashima Y, Kita K, et al. Primary synovial sarcoma of the kidney. Case Rep Oncol. 2009;2:189–93.
Published
2015-12-28
Issue
Section
Case Reports
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