Effect of Vit. B12 supplementation on auditory neuropathy in type 2 Diabetic patients assesssed by Brainstem Auditory Evoked Response
Keywords:
Diabetes mellitus, Vitamin B12, BAER, auditory neuropathy
Abstract
Background: Diabetes mellitus is one of the leading causes of neuropathy across the globe. Peripheral neuropathy is explored in most of the studies so far,In our study we tried to identify abnormalities in auditory nerve making the use of brainstem auditory evoked potential1,2,.Methods: The patients were categorized into two groups, Group I includes patients who received Vit. B12 and group II includes patients who received placebo. Patients in both the groups were also taking gabapentin and antidiabetic treatment. Details of the patient, symptoms, history of diabetes, Fasting blood sugar,S. Vit. B12 level and Latencies of BAER were monitored at baseline and then periodically till 16 weeks.Results: We found improvement in latency of BAER of both ears were significant in diabetic patients who received Vit. B12 than those taking placebo.Conclusion: Abnormalities in brainstem auditory evoked potentials can be detected in diabetic patients even in the absence of clinical symptoms. Improvement in latencies of waves is seen after supplementation of vit. B12 as assessed by brainstem auditory evoked potentials. Although promising, further studies are needed to assess long term treatment of Vit. B12 in large sample of population.References
1. Gupta R, Aslam M, Hasan SA and Siddiqi SS. Type-2 diabetes mellitus and auditory brainstem responses-a hospital based study. Indian J Endocrinol Metab 2010; 14(1): 9-11.
2. Bayazit Y, Yilmaz M, Kepekçi Y, Mumbuç S, Kanlikama M. Use of the auditory brainstem response testing in the clinical evaluation of the patients with diabetes mellitus. J Neurol Sci. 2000;181(l-2):29–32.
3. Durmus C, Yetiser S, Durmus O. Auditory brainstem evoked responses in insulin-dependent (ID) and non-insulin-dependent (NID) diabetic subjects with normal hearing. International J of Audiology.2004;43(1):29–33.
4. Toth, et al. Brainstem auditory evoked potential examinations in diabetic patients. Scandinavian Audiology. 2001;30:156–159.
5. Pflipsen M, Oh R, Saguil A, Seehusen D, Topolski R. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Cross-Sectional Study. J Am Board Fam Med. 2009;22:528–34.
6. Sharma R, Gupta SC, Tyagi I et al. Brain Stem Evoked Responses in patients with Diabetes Mellitus. Indian J of Otolaryngology and Head and Neck Surgery 2000;52(3); 221- 229.
7. Demir N, Koc A, Üstyol L, Peker E, Abuhandan M. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child H 2013; 49: 820–824.
8. Fine EJ, Soria E, Paroski MW, Petryk D, Thomasula L. The neurophysiological profile of vitamin B12 deficiency. Muscle Nerve 1990; 13: 158–164.
9. Markand ON. Brainstem auditory evoked potentials. J Clin Neurophysiol 1994; 11: 319–342.
10. Misra UK, Kalita J, Das A. Vitamin B12 deficiency neurological syndromes: a clinical, MRI and electrodiagnostic study. Electromyo Clin Neur 2003; 43: 57–64.
11. Jawa AA, Akram J, Sultan M, Humayoun MA, Raza R. Nutrition-related vitamin B12 deficiency in patients in Pakistan with type 2 diabetes mellitus not taking metformin. Endocr Pract 2010;16:205-8.
12. Ramachandran A, Snehalatha C, Shetty A, Nanditha A. Trends in prevalence of diabetes in Asian countries. World J Diabetes. 2012;3(6):110.
2. Bayazit Y, Yilmaz M, Kepekçi Y, Mumbuç S, Kanlikama M. Use of the auditory brainstem response testing in the clinical evaluation of the patients with diabetes mellitus. J Neurol Sci. 2000;181(l-2):29–32.
3. Durmus C, Yetiser S, Durmus O. Auditory brainstem evoked responses in insulin-dependent (ID) and non-insulin-dependent (NID) diabetic subjects with normal hearing. International J of Audiology.2004;43(1):29–33.
4. Toth, et al. Brainstem auditory evoked potential examinations in diabetic patients. Scandinavian Audiology. 2001;30:156–159.
5. Pflipsen M, Oh R, Saguil A, Seehusen D, Topolski R. The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Cross-Sectional Study. J Am Board Fam Med. 2009;22:528–34.
6. Sharma R, Gupta SC, Tyagi I et al. Brain Stem Evoked Responses in patients with Diabetes Mellitus. Indian J of Otolaryngology and Head and Neck Surgery 2000;52(3); 221- 229.
7. Demir N, Koc A, Üstyol L, Peker E, Abuhandan M. Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment. J Paediatr Child H 2013; 49: 820–824.
8. Fine EJ, Soria E, Paroski MW, Petryk D, Thomasula L. The neurophysiological profile of vitamin B12 deficiency. Muscle Nerve 1990; 13: 158–164.
9. Markand ON. Brainstem auditory evoked potentials. J Clin Neurophysiol 1994; 11: 319–342.
10. Misra UK, Kalita J, Das A. Vitamin B12 deficiency neurological syndromes: a clinical, MRI and electrodiagnostic study. Electromyo Clin Neur 2003; 43: 57–64.
11. Jawa AA, Akram J, Sultan M, Humayoun MA, Raza R. Nutrition-related vitamin B12 deficiency in patients in Pakistan with type 2 diabetes mellitus not taking metformin. Endocr Pract 2010;16:205-8.
12. Ramachandran A, Snehalatha C, Shetty A, Nanditha A. Trends in prevalence of diabetes in Asian countries. World J Diabetes. 2012;3(6):110.
Published
2016-05-26
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