Morphological spectrum of changes in gall bladder in correlation to various types of gallstones: a study of 100 cases

  • Meenakumari Gopalakrishnan PROFESSOR OF PATHOLOGY,MADURAI MEDICAL COLLEGE,MADURAI,TAMILNADU
  • Sharmila Thilagavathy
  • Kamaleshwari .
  • Jeyanthi .
  • Shifa .
  • Raasi .
Keywords: cholesterol, hyperplasia, metaplasia, carcinoma.

Abstract

Background: Gallstones  are a common cause of morbidity world wide. Presence of gallstones in gallbladder results in diverse histological changes. Some of them could be precursor lesions for malignancy. This study was aimed to correlate the various histological changes in the gallbladder to the chemical composition of gallstones whether it was cholesterol, mixed or pigment variety.Method : We analysed gallbladders of 100 patients who underwent cholecystectomy for gall stones.The age ,sex distribution and the incidence of different types of gallstones were studied.The histological changes in the gallbladders were observed and correlation  with the type of gallstones was evaluated.Result: Gallstones were more common in the 40 -49 age group with increased  incidence in females. Many histological changes including hyperplasia ,lymphoid follicles ,prominent RokitanskyAschoff sinuses, muscular hypertrophy, metaplasia and carcinoma were observed. Most of these histological changes were seen in the gallbladders with cholesterol stones. Hyperplasia  was observed in 31.5%,lymphoid follicles in 31.5% ,RokitanskyAshoff sinus in 36.8%, muscular hypertrophy in 47.3%,pyloric metaplasia in  26% of gallbladders with cholesterol stones. Intestinal metaplasia  was commonly associated with pigment stones(11%) and carcinoma was seen in gallbladders with mixed stones (6.7%).Conclusion: Gallstones are common in the adult population with a female predominance. Mixed stones were the common stones encountered . Correlation of histological changes with the chemical composition of gallstones showed increased incidence of  changes  in gallbladders with cholesterol stones.This could be due to the larger size of the cholesterol stones leading to more irritation and chemical injury produced by lithogenic bile.  

Author Biography

Meenakumari Gopalakrishnan, PROFESSOR OF PATHOLOGY,MADURAI MEDICAL COLLEGE,MADURAI,TAMILNADU
PROFESSOR  OF  PATHOLOGY,MADURAI  MEDICAL  COLLEGE,MADURAI,TAMILNADU

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Published
2016-06-15
Issue
Vol 3 No 2 (2016)
Section
Original Article

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