Histomorphological spectrum of skin adnexal tumours : a retrospective study in a tertiary care centre
Keywords:
Genetic inherited syndrome, Hair follicle, Eccrine, Apocrine differentiation.
Abstract
Background: Skin Adnexal Tumours (SATs ) are large and divergent group of tumours which are classified based on their appendageal differentiation into eccrine,follicular,sebaceous and apocrine.They pose daunting diagnostic challenges to both clinicians and pathologists alike.This study aims to evaluate the histopathological charecterestics of skin adnexal neoplasms and correlate with their clinical profile.Methods : This is a retrospective study of skin adnexal tumours (28 cases) diagnosed on histopathological examination over a period of two years .( January 2014 to December 2015 ).Results: Skin adnexal tumours are uncommon lesions with an incidence of 0.27%.These tumours were common in the 51 to 60 age group and showed a female preponderance. Head and neck region particularly the scalp was commonly involved. Benign tumours were more common (78.6% ) than the malignant ones (21.4%). .Sweat gland tumours constituted the largest group (61%) followed by hair follicle tumours (21%)and sebaceous tumours (14%).Apocrine gland tumours were less common. Nodular hidradenoma was the most common benign tumour and sebaceous carcinoma was the most common malignant tumour encountered in the present study.Conclusion :SATs are relatively uncommon lesions and have distinct histopathological features. Clinical diagnosis is difficult as most of these lesions are nondescript and histopathological examination is essential for its diagnosis.References
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2. Stantaylor R, Perone J.B, Kaddu S and Kerlh . Appendage tumors and hamartomas of the skin , in Fitzpatricks Dermatology in General Medicine, K. Wolff, L. Goldsmith, S. Katz , B.A. Gilchrest, A.S. Paller and D.J. Leffell, Eds., 7th edition, McGraw Hill, New York, NY, USA, 2008:1068-1087.
3. Elder D, Murphy G, Rubin A. Lever`s Histopathology of skin. In : Tumors of the epidermal appendages. Campbell L ,Stewart ,Robert A , Novoa,John T .Seykora.In: editors. 11th ed. Philadelphia: Wolters Kluwer; 2015.
4. Chayanika Pantola,Sanjay Kala,Asha Agarwal,Sonal Amit ,Saurabh Pantola.Cutaneous Adnexal Tumours: A Clinicopathological Descriptive study of 70 cases.World Journal of Pathology 2013;2:13
5. Sharma A,Paricharak D G, Nigam J S ,Rewri S,Soni P B,Omhare A et al, Histopathological study of Skin Adnexal Tumours – Institutional Study in South India,Journal of Skin Cancer 2014 .(2014)
6. Vani D,Ashwini N .S, Sandhya M, Dayananda T.R, Bharathi M. A 5 year histopathological study of skin adnexal tumours at a tertiary care hospital. IOSR Journal of Dental and Medical Sciences.2015;4:1-5.
7. .Radhika K ,Phaneendra BV , .Rukmangadha N, Reddy MK.A study of biopsy confirmed skin adnexal tumours:experience at a tertiary teaching hospital. J Clin Sci Res 2013:2:132 -8.
8. Giovanni Ponti ,Giovanni Pellacani,Stefania Seidenari et al .Cancer -associated genodermatosis:Skin neoplasms as clues to heriditary tumour syndrome. Crit Rev Oncol Hematol. 2013;85(3): P.239-56.
9. Sri Gayathri S, Ezhilvizhi Alavandar,Ashok Kumar.An Analysis of skin appendageal Tumors in South India.Journal of Evolution of Medical and Dental Sciences.2013;1(6):907 -912.
10. Kanitakis. Adnexal tumours of skin as markers of cancer -prone syndromes. J Eur Acad Dermatol Venereol. 2010;24(4): P. 379-87.
11. Joost J.van den Oord,Chris De Wolf –Peters:Perivascular spaces in eccrine spiradenoma – A clue to its histological diagnosis.Am J Dermatopath.17(3):266-270,1995.
12. N A Obaidat, K O Alsaad, D Ghazarian .Skin adnexal neoplasms part-2;An approach to tumors of cutaneous sweat glands. J Clin Pathol. 2007;60: P. 145 - 159.
13. Hesari K, Balighi K, Afshar et al N. Cilinicopathological study of 1016 consecutive Adnexal Skin Tumors. Acta Medica Iranica. 2013;15(12): P. 879-85.
14. A Neil Crowson , Cynthia M , Margo , Martin C.Malignant adnexal neoplasms.Modern Pathology, 2006 ;19:P. S 93 – S 126.
Published
2016-08-10
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