Study of haematological profile of Dengue Fever and its clinical implication

  • Vibha Vipulbhai Gajera Mahatma Gandhi Mission University of Health Sciences.
  • Shilpi Sahu
  • Reeta Dhar
Keywords: Dengue, thrombocytopenia, DHF, DSS


Background: Dengue virus, a mosquito-borne human viral pathogen, has recently become a major national health problem.The disease is transmitted in rainy season. There are four dengue virus serotypes, called DEN-1, DEN-2, DEN-3, and DEN-4. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. Laboratory diagnosis of dengue virus infection depends upon demonstration of specific antibodies in serum samples. Early diagnosis and monitoring is largely dependent on haematological  parameters. As no specific antiviral therapy is available, supportive therapy is of most importance.Methods: NS1, Ig M & Ig G detection by Dengue Day 1 Test kit, haematological parameters by automated analyzer & peripheral smear, coagulation profile analysis by ACL-7000 coagulation meter, LFT by BACKMAN COULTER AU480.Result: Out of 100 cases, 95 (95%) of the patients had fever, 39 (39%) cases had leukocyte count <4,000/ mm3, thrombocytopenia (<1,00,000/mm3) was observed in 81, 48 cases had derranged LFT with thrombocytopenia,17 cases had prolonged APTT which correlated  with thrombocytopenia, 14 cases had raised APTT & deranged  LFT which also showed thrombocytopenia.Conclusion:Thrombocytopenia was most predominant haematological discrepancy. Most cases (70%) were of classical DF & (28%) were cases of DHF who had fever, showed thrombocytopenia & deranged haematological parameters which signifies disease severity. 2% cases presented with hypotension & altered consciousness with severe thrombocytopenia & prolonged APTT (DHF/DSS) which indicates very poor prognosis & had fatal outcome. Initial leukopenia & leukocyte count returning to normal by ninth to tenth day after therapy in most of the cases indicates that leukocyte count an important benchmark for clinical improvement. Dengue fever does not have specific medical therapy hence clinical recovery monitoring is largely dependent on haematological  parameters. 

Author Biography

Vibha Vipulbhai Gajera, Mahatma Gandhi Mission University of Health Sciences.
MD Pathology


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