Importance of Pre-Transplant Vaccination in Reducing Rotavirus Infection in Post-Transplant Patients

  • Hamza H Khan MedStar Georgetown University Hospital, Washington, DC
  • Ahmed R Alhabib MedStar Georgetown University Hospital, Washington, DC
  • Abdullah Karabala MedStar Georgetown University Hospital, Washington, DC
  • Khalid M Khan MedStar Georgetown University Hospital, Washington, DC
  • Stuart S Kaufman MedStar Georgetown University Hospital, Washington, DC
  • Nada A Yazigi MedStar Georgetown University Hospital, Washington, DC
Keywords: Rotavirus infection, Rotavirus vaccination, Transplant patients, Economic burden, Health burden


Rotavirus is a highly contagious member of the Reoviridae family. It is the most common cause of diarrhea in the pediatric population. In this review, all the transplant pediatric patients admitted to our institute from January-May 2017 were reviewed. The inclusion criteria of our study included a chief complaint of diarrhea and a positive test for rotavirus with no confounding cause for the symptoms or for the admission. Based on the available data it can be concluded that administration of rotavirus vaccine in patients with intestinal failure prior to intestinal transplant can significantly decrease the incidence of rotavirus enteritis. Since the maximum recommended age for last dose of either vaccine is 32 weeks, therefore early vaccination as part of routine immunization is very important. This will improve the overall morbidity and mortality as well as the health-related financial burden on the hospital and economy.


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Original Article