Case of Acquired stomatocytosis in an alcoholic patient
Keywords:
Stomatocytes, alcoholism, peripheral blood examination
Abstract
We present a case of acquired stomatocytosis in red blood cells of a middle aged alcoholic male, who presented with mild anemia. Stomatocytes are erythrocytes with a central slit or mouth-shaped area a central pallor. The pathology lies in decreased activity of sodium potassium membrane pump leading to increased sodium influx causing cell swelling inducing stomatocytosis. The increased dependence on automated hematology analyzers and minimum use of peripheral blood smear examination in modern time necessities the need of peripheral blood smear examination.References
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2. Mentzer WC Jr, Smith WB, Goldstone J, Shohet SB. Hereditary stomatocytosis: membrane and metabolism studies. Blood 1975; 46:659–669.
3. Wislöff F, Boman D. Acquired stomatocytosis in alcoholic liver disease. Scand J Haematol 1979 Jul; 23(1):43–50.
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8. Fricke B, Parsons SF, Knopfle G, et al. Stomatin is mis trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes. Br J Haematol 2005;131: 265–277
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10. Zhu Y, Paszty C, Turetsky T, et al. Stomatocytosis is absent in “stomatin”-deficient murine red blood cells. Blood 1999; 93:2404–2410.
11. Gallagher PG, Chang SH, Rettig MP, et al. Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis. Blood 2003; 101:4625–4627.
2. Mentzer WC Jr, Smith WB, Goldstone J, Shohet SB. Hereditary stomatocytosis: membrane and metabolism studies. Blood 1975; 46:659–669.
3. Wislöff F, Boman D. Acquired stomatocytosis in alcoholic liver disease. Scand J Haematol 1979 Jul; 23(1):43–50.
4. Glader BE, Fortier N, Albala MM, Nathan DG. Congenital hemolytic anemia associated with dehydrated erythrocytes and increased potassium loss. N Engl J Med 1974; 291:491–496.
5. Delaunay J. The hereditary stomatocytoses: genetic disorders of the red cell membrane permeability to monovalent cations. Semin Hematol 2004; 41: 165–172.
6. Stewart GW, Turner EJ. The hereditary stomatocytoses and allied disorders: congenital disorders of erythrocyte membrane permeability to Na and K. Baillieres Best Pract Res Clin Haematol 1999; 12:707–727.
7. Fricke B, Argent AC, Chetty MC, et al. The “stomatin” gene and protein in overhydrated hereditary stomatocytosis. Blood 2003; 102:2268–2277.
8. Fricke B, Parsons SF, Knopfle G, et al. Stomatin is mis trafficked in the erythrocytes of overhydrated hereditary stomatocytosis, and is absent from normal primitive yolk sac-derived erythrocytes. Br J Haematol 2005;131: 265–277
9. Lande WM, Thiemann PV, Mentzer WC Jr. Missing band 7 membrane protein in two patients with high Na, low K erythrocytes. J Clin Invest 1982; 70: 1273–1280.
10. Zhu Y, Paszty C, Turetsky T, et al. Stomatocytosis is absent in “stomatin”-deficient murine red blood cells. Blood 1999; 93:2404–2410.
11. Gallagher PG, Chang SH, Rettig MP, et al. Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis. Blood 2003; 101:4625–4627.
Published
2017-12-16
Issue
Section
Case Report
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