A Correlation between Tuberculosis Infection and Coagulation Parameters (In Mile Four Hospital, Abakaliki)

  • Albert N Eteudo Ebonyi State University, Abakaliki, Ebonyi State
  • Chuks Oswald Edeogu Ebonyi State University, Abakaliki, Ebonyi State
  • Igube Anthony Nwovu Federal Teaching Hospital, Ebonyi State
  • Clara Kela-Eke University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu
  • Simon Onyema Azi Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State
  • Chinwe Ezeruigbo Department of Nursing Science, Ebonyi State University, Abakaliki, Ebonyi State
  • Chituru June Orioha Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State
Keywords: Tuberculosis, Coagulation, Prothrombin time, Thrompoblastin, Platelet

Abstract

Background: The processes of inflammation and coagulation are known to be interconnected through a threesome mechanism (platelet activation, endogenous anticoagulant down-regulation and fibrinolysis inhibition). The present study was aimed at determining the correlation between tuberculosis and coagulation parameters among tuberculosis patients in Mile 4 Hospital, Abakaliki.Methods: A total of 270 venous blood samples (180 from tuberculosis patients and 90 from non-tuberculosis subjects {as control}) were collected and assayed for prothrombin time, activated partial thromboplastin time and platelet count using standard clotology techniques.Results: The mean coagulation parameters - aPTT, PT and platelet count, of the patient group (46.09±8.79 sec, 15.53±3.35 sec and 286.33±101.09 x109/L respectively) was higher than that of the control group (30.75±4.06 sec, 13.60±1.64 sec and 238.20±92.19 x109/L respectively). Significant difference between the two groups was noted in the mean PT and aPTT (p<0.05). The result also showed that the mean value of the coagulation parameters, aPTT, PT (15.93 sec) and platelet count (292.39 x109/L) (among the tuberculosis patients) of the male gender was higher compared to the female gender (43.56 sec, 15.26 sec and 277.25 x109/L respectively). The difference in mean with respect to sex was statistically insignificant (p>0.05). Positive correlation exist between PT and platelet count; aPTT and platelet count and aPTT and PT.Conclusion: It will suffice to say that there is a correlation between tuberculosis and coagulation pathway. Also, a positive relationship exist between parameters of the intrinsic (aPTT) and extrinsic (PT) coagulation pathway.

Author Biographies

Albert N Eteudo, Ebonyi State University, Abakaliki, Ebonyi State
Head, Department of Anatomy, Ebonyi State University, Abakaliki, Ebonyi State
Chuks Oswald Edeogu, Ebonyi State University, Abakaliki, Ebonyi State
Dean, Faculty of Health Sciences & Technology, Ebonyi State University, Abakaliki, Ebonyi State
Igube Anthony Nwovu, Federal Teaching Hospital, Ebonyi State
Director, Medical Laboratory Services, Federal Teaching Hospital, Ebonyi State
Clara Kela-Eke, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu
Ass. Director, Medical Laboraotry Services, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu
Simon Onyema Azi, Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State
Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State
Chinwe Ezeruigbo, Department of Nursing Science, Ebonyi State University, Abakaliki, Ebonyi State
Head, Department of Nursing Science, Ebonyi State University, Abakaliki, Ebonyi State
Chituru June Orioha, Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State
Medical Laboratory Science, Ebonyi State University, Abakaliki, Ebonyi State

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Published
2017-12-19
Section
Original Article