Polycystic ovary syndrome and vitamin D, where do we stand?
Abstract
In recent years, a correlation between vitamin D deficiency (VDD) and polycystic ovary syndrome (PCOS) has been suggested. Our attention has been drawn to vitamin D having effects other than those related to calcium homeostasis, specifically those concerning the reproductive process.In this article we discuss the role of vitamin D on women with PCOS and the recommendations on vitamin D supplementation for these women.References
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11. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is animportant factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000;141:1317–24;
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13. Halhali A, Acker GM, Garabedian M. 1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. J Reprod Fertil 1991; 91:59–64 ;
14. Harkness LS, Bonny AE. Calcium and vitamin D status in the adolescent: key roles for bone, body weight, glucose tolerance, and estrogen biosynthesis. J Pediatr Adolesc Gynecol 2005; 18:305–11
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16. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96:1911–30.
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18. Muscogiuri G et al. Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders. 2017.
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23. Mykhalchenko K , Lizneva D, Trofimova T, Walker W, Suturina L, Diamond M.P. et al. Genetics of polycystic ovary syndrome. Expert Review of Molecular Diagnostics, 2017.
24. Irani M, Seifer DB et al. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D- Deficient Women with PCOS: A Randomized Placebo- Controlled Trial. Nutrients. 2017 28;9
25. Irani M, Seifer D. et al. Vitamin D supplementation decreases TGF-ß1 bioavailability in PCOS: A randomized placebo controlled trial. J Clin Endocrinol Metab 2015; 100 (11): 4307-14.
26. Irani M, Minkoff H, Seifer DB, Merhi Z, Vitamin D. Increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014;99:E886–90.
27. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol / European Federation of Endocrine Societies. 2009;161(4):575– 82.
28. Pittas AG, Chung M, Trikalinos T, Mitri J,. Brendel M, Patel K, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010;152(5):307–14.
29. Patra SK, Nasrat H, Goswami B, Jain A. Vitamin D as predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012;6:146–9
30. Luk, Torrealday, et al. Relevance of vitamin D in reproduction. Human Reproduction. 2012; 27 (10): 3015-3027
31. Zadeh-Vakili A, Ramezani TF, Daneshpour MS, Zarkesh M, Saadat N, Azizi F. Genetic polymorphism of vitamin D receptor gene affects the phenotype of PCOS. Gene 2013;515:193–6.
32. Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77(3):343-50)
33. Drakopoulos P. Et al. The effect of serum vitamin D levelson ovarian reserve markers: a prospective cross-sectional study. Hum Reprod 2017; 32 (1): 208-214.
34. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011 34:757–763
35. Rondanelli et al. Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Arch Gynecol Obstet 2014; 290:1079-1092
36. Lerchbaum E., Rabe T., Vitamin D and female fertility. Curr Opin Obstet Gynecol 2014, 26: 145-150.
37. Pal L, Zhang H. Et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: secondary analysis of a multicenter randomized controlled trial. J Clin Endocrinol Metab. 2016; 101(8): 3027-3035
2. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006; 92: 4-8.
3. Ashwell M, Stone EM, Stolte H, Cashman KD, Macdonald H,Lanham-New S, et al. UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status. Br J Nutr 2010;104:603–611.
4. Moore C, Murphy MM, Keast DR, Holick MF. Vitamin D intake in the United States. J Am Diet Assoc 2004;104:980–983.
5. Schuster I. Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta 2011;1814:186–199.
6. Christakos S, Dhawan P, Benn B, Porta A, Hediger M, Oh GT, et al. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci 2007;1116:340–348.
7. Barsony J, Renyi I, McKoy W. Subcellular distribution of normal and mutant vitamin D receptors in living cells. Studies with a novel fluorescent ligand. J Biol Chem. 1997; 272: 5774-82.)
8. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–81;
9. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D–mediated human antimicrobial response. Science 2006;311:1770–3
10. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013;67:225–235.
11. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is animportant factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000;141:1317–24;
12. Hurley WL, Doane RM. Recent developments in the roles of vitamins and minerals in reproduction. J Dairy Sci 1989;72:784–804;
13. Halhali A, Acker GM, Garabedian M. 1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. J Reprod Fertil 1991; 91:59–64 ;
14. Harkness LS, Bonny AE. Calcium and vitamin D status in the adolescent: key roles for bone, body weight, glucose tolerance, and estrogen biosynthesis. J Pediatr Adolesc Gynecol 2005; 18:305–11
15. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842–856
16. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96:1911–30.
17. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord 2017
18. Muscogiuri G et al. Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders. 2017.
19. Azziz, R. et al. Polycystic ovary syndrome. Nat Rev Dis Primers, 2016. 2: p. 16057
20. Govind A., M.S. Obhrai, and R.N. Clayton. Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J Clin Endocrinol Metab, 1999. 84(1): p. 38-43.
21. Vink, J.M., et al., Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab, 2006. 91(6): p. 2100-4.
22. Rotterdam, E.A.-S.P.C.W.G., Revised 2003 consensus on diagnostic criteria and long-termhealth risks related to polycystic ovary syndrome. Fertil Steril, 2004. 81(1): p. 19-25.
23. Mykhalchenko K , Lizneva D, Trofimova T, Walker W, Suturina L, Diamond M.P. et al. Genetics of polycystic ovary syndrome. Expert Review of Molecular Diagnostics, 2017.
24. Irani M, Seifer DB et al. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D- Deficient Women with PCOS: A Randomized Placebo- Controlled Trial. Nutrients. 2017 28;9
25. Irani M, Seifer D. et al. Vitamin D supplementation decreases TGF-ß1 bioavailability in PCOS: A randomized placebo controlled trial. J Clin Endocrinol Metab 2015; 100 (11): 4307-14.
26. Irani M, Minkoff H, Seifer DB, Merhi Z, Vitamin D. Increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014;99:E886–90.
27. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera D, Pieber TR, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol / European Federation of Endocrine Societies. 2009;161(4):575– 82.
28. Pittas AG, Chung M, Trikalinos T, Mitri J,. Brendel M, Patel K, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010;152(5):307–14.
29. Patra SK, Nasrat H, Goswami B, Jain A. Vitamin D as predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012;6:146–9
30. Luk, Torrealday, et al. Relevance of vitamin D in reproduction. Human Reproduction. 2012; 27 (10): 3015-3027
31. Zadeh-Vakili A, Ramezani TF, Daneshpour MS, Zarkesh M, Saadat N, Azizi F. Genetic polymorphism of vitamin D receptor gene affects the phenotype of PCOS. Gene 2013;515:193–6.
32. Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77(3):343-50)
33. Drakopoulos P. Et al. The effect of serum vitamin D levelson ovarian reserve markers: a prospective cross-sectional study. Hum Reprod 2017; 32 (1): 208-214.
34. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011 34:757–763
35. Rondanelli et al. Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Arch Gynecol Obstet 2014; 290:1079-1092
36. Lerchbaum E., Rabe T., Vitamin D and female fertility. Curr Opin Obstet Gynecol 2014, 26: 145-150.
37. Pal L, Zhang H. Et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: secondary analysis of a multicenter randomized controlled trial. J Clin Endocrinol Metab. 2016; 101(8): 3027-3035
Published
2018-03-28
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