Clinical and Histopathological Spectrum of Salivary Gland Lesions in A Tertiary Center
Abstract
Background: The objective of this study was to determine the clinical pattern and histopathological features of salivary gland lesions (SGL) in patients presenting to a tertiary hospital in Southwest Saudi Arabia. Methods: A retrospective study was conducted in histopathology section of Department of Laboratory Medicine from January 2014 to February 2018 on tissue specimens from salivary gland lesions. The histopathological diagnosis was made according to World health organization classification (2017) based on light microscopy followed by special stains and immunohistochemistry wherever necessary. Results: A total of 70 specimens were received in hospital during this period. These comprised of 8 inflammatory lesions and 62 tumors. Salivary gland tumors involved 29 males and 33 females, male: female ratio= 0.8:1 with mean age of 44.5 years. 46 (74.2%) were benign and 16 (25.8 %) were malignant. Parotid gland was involved in 47, submandibular gland in 4, sublingual gland in 3 and minor salivary glands in 8 cases. Conclusions: Our study revealed that tumors are the commonest lesions in specimens of salivary gland masses with pleomorphic adenomas being the predominant tumor (51.6%) . Parotid was the most commonly involved gland with majority of the tumors being benign (82.9%). Submandibular gland was involved by benign lesions in 87.5 % cases out of which 50 % were inflammatory in nature . Sublingual and minor salivary glands were predominantly affected by malignant tumors constituting 70 % of cases.References
Kumar V, Abbas A K , Aster J C. Robbins and Cotran pathologic basis of disease ,Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.
Salivary gland tumors.In: EI-Naggar AK, Chan JKC, Grandis JR , Takata T, Slootweg PJ .World Health Organization Classification of Head and Neck Tumours. Lyon: IARC Press; 2017.
Rosai J, Ackerman L: Surgical Pathology, ed 11.New York, Mosby, 2017.
Pieterse AS, Seymour AE. Parotid cysts. An analysis of 16 cases and suggested classification. Pathology. 1981;13(2):225-234.
Wu L, Cheng J, Maruyama S, et al.Lymphoepithelial cyst of the parotid gland: its possible histopathogenesis based on clinicopathologic analysis of 64 cases. Hum Pathol. 2009;40(5):683-692.
Johns M, Goldsmith M. Incidence, diagnosis and classification of salivary gland tumours-Part. Oncology (Huntingt). 1989;3(2):47-56.
Jaafari-Ashkavandi1 Z, Ashraf MA, Moshaverinia M. Salivary Gland Tumors: A Clinicopathologic Study of 366 Cases in Southern. Iran Asian Pacific Journal of Cancer Prevention,14 (1), 27-30 2013 .DOI :http :// dx. doi. org/ 10.73 14/ APJCP .2013.14.1.27
Sando Z, Fokouo JV, Mebada AO, Djomou F, NDjolo A, Oyono JLE. Epidemiological and histopathological patterns of salivary gland tumors in Cameroon. Pan African Medical Journal. 2016; 23:66 doi:10.11604/pamj.2016.23.66.5105
Vuhahula E. Salivary gland tumors in Uganda: clinical pathological study. African health sciences. 2004 Apr;4(1):15-23. PubMed | Google Scholar
Subhashraj K . Salivary gland tumors: a single institution experience in India. Br J Oral and Maxillofac Surg 2008; 46, 635-8.
Elhakim MT, Breinholt H, Godballe C, Andersen LJ, Primdahl H, Kristensen CA, et al. Polymorphous low-grade adenocarcinoma: a danish national study. Oral Oncol. 2016; 55:6–10.
Skalova A, Sima R, Kaspirkova-Nemcova J, Simpson RH, Elmberger G, Leivo I, et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol. 2011;35(8):1168–76.
Westra WH, Lewis Jr. JS. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Oropharynx. Head and Neck Pathol.2017; 11:41–47. DOI 10.1007/s12105-017-0793-2
Speight PM, Barrett A. Salivary gland tumours. Oral Dis. 2002 Sep;8(5):229-40. PubMed | Google Scholar
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