Minimal deviation adenocarcinoma and its mimickers: a case report with review of literature

  • Manjula Jain Director Professor and Head, Department of Pathology, Lady Hardinge Medical College and Smt S.K. Hospital, Shaheed Bhagat Singh Marg, New Delhi 110001, India
  • Savita Agarwal Department of Pathology, Lady Hardinge Medical College and Smt S.K. Hospital, Shaheed Bhagat Singh Marg, New Delhi 110001, India
  • Sonal Malhotra
Keywords: Minimal deviation adenocarcinoma, tunnel clusters, lobular endocervical hyperplasia, endocervicosis, florid deep glands, Immunohistochemistry.


Amongst all the glandular lesions of the cervix, minimal deviation adenocarcinoma (MDA) the, so called Adenoma-malignum and its mimickers have been the subject of great interest in the literature. Although a rare entity, MDA commonly requires consultancy to distinguish it from many benign cervical glandular lesions.MDA is a unique neoplasm of the uterine cervix, characterized by mucinous glands with deceptively benign histological appearance posing difficulty in its diagnosis.In the present case report MDA was an incidental finding in a 45 year old female, on the hysterectomy specimen submitted for multiple leiomyomas, and the diagnosis was based on histopathological and immunohistochemical (IHC) findings.


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Case Report