A case report of Menetrier’s disease

Maithili Arun Gangurde, Rachana Amit Chaturvedi, Amita Joshi

Abstract


Menetrier’s disease (MD) is a rare premalignant disorder of unknown etiology, characterized by giant hypertrophic folds involving fundus, with antral sparing. Microscopy shows hyperplasia and corkscrew appearance of gastric foveolae, often associated with prominent eosinophilic inflammatory infiltrate. Common presentation is pain, vomiting, diarrhea and hypoproteinemia. Differential diagnoses include polyposis and infiltrating disorders, and gastrectomy recommended if debilitating disease or risk of carcinoma. A 50-year-old male presented with abdominal pain, vomiting and hypoproteinemia. Radiology and endoscopy showed thickened gastric folds and biopsy suggested a possibility of eosinophilic gastritis or MD. Total gastrectomy specimen and microscopy showed a classical appearance of MD. Exact incidence of MD in India is not known. Diagnosis can be missed on biopsy and adequate sampling with follow-up is essential due to associated risk of malignancy.

DOI: 10.21276/APALM.1622


Keywords


Menetrier disease, corkscrew, foveolar hyperplasia, hypertrophied gastric folds

Full Text:

PDF

References


Azer M, Sultan A, Zalata K, Abd El-Haleem I, Hassan A, El-Ebeidy G. A case of Menetrier’s disease without Helicobacter pylori or hypoalbuminemia. Int J Surg Case Rep. 2015;17:58-60.

Coffey RJ, Washington MK, Corless CL, Heinrich MC. Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest. 2007;117(1):70-80.

Friedman J, Platnick J, Farruggia S, Khilko N, Mody K, Tyshkov M. Menetrier Disease.Radiographics.2009;29:297-301.

Stamp GW, Palmer K, Misiewicz JJ. Antral hypertrophic gastritis: a rare cause of iron deficiency. J Clin Pathol. 1985;38(4):390-392.

Burdick J.S, Chung E, Tanner G, Sun M, Paciga JE, Cheng JQ. Treatment of Menetrier’s Disease with a Monoclonal Antibody against the Epidermal Growth Factor Receptor. N Engl J Med .2000; 343:1697-1701.

Sweeney AR, Lynch MK. A case of Ménétrier’s disease localized to the gastric antrum without helicobacter infection or hypoalbuminemia. Int J Surg Case Rep.2013;4(10):839-841.

Rich A, Toro TZ, Tanksley J, Fiske WH, Lind CD, Ayers GD et al.Distinguishing Ménétrier’s disease from its mimics.Gut.2010;59:1617-1624.

Lakshmi TS, Rao PN, Nagaria M. Primary pachydermoperiostosis associated with Menetrier’s disease. Indian J Dermatol Venereol Leprol.2001;67(5):256-8.

Chakrabarti AK, Singh TD, Joshi K, Malik AK. Ménétrièr’s disease and trichobezoar of stomach-an unusual association. Postgrad Med J. 1983;59(693):464-466.


Refbacks

  • There are currently no refbacks.




Creative Commons License
Annals of Pathology and Laboratory Medicine (APALM) is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at APALM