Idiopathic Giant Cell Myocarditis
A Report of 2 Cases
Keywords:
Myocarditis, Giant cell myocarditis, sudden cardiac death
Abstract
Two cases of idiopathic giant cell myocarditis are reported for their rarity .The first case was of a 47 years old male brought to hospital with a history of uneasiness and sudden death. The second case was of a 55 years old male. Gross examination of heart showed whitish fibrotic areas. Microscopy of the heart in both cases revealed large confluent areas of myocyte necrosis along with plenty of giant cells and lymphocytes and occasional eosinophils. Ziehl Neelsen (ZN ) and periodic acid Schiff (PAS) stains were negative. There were no asteroid bodies or Schumann bodies in the giant cells.References
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2. Kalpana Kumari MK, Mysorekar Vijaya, Praveen S. Idiopathic giant cell myocarditis: a case report. Journal of clinical and diagnostic research.2012; 6(8):1425-1427.
3. Leslie T Cooper , Gerald J Berry, Ralph Shabetai. Idiopathic giant cell myocarditis-natural history and treatment. NEJM, 1997;336(26):1860-1866.
4. Litovsky SH, Burke AP, Virmani R. Giant cell myocarditis: an entity distinct from sarcoidosis characterized by multiphasic myocyte destruction by cytotoxic T cells and histiocytic giant cells. Mod Pathol. 1996 ; 9(12):1126-34.
5. Rosenstein ED , Zucker MJ, Kramer N. Giant cell myocarditis: most fatal of autoimmune diseases. Semin Arthritis Rheum. 2000 ; 30(1):1-16.
6. Singh H, Kundal R. Idiopathic systemic granulomatous pathology causing sudden death due to myocarditis: a rare case report. Indian J Pathol Microbiol. 2015 ; 58(1):99-101.
Published
2018-06-17
Issue
Section
Case Report
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