Multiple cutaneous metastasis of sacral chordoma, mimicking neurofibromas clinically
Keywords:
Cutaneous metastasis, Sacral Chordoma, Neurofibroma
Abstract
Chordoma is a rare primary bone tumor of notochordal origin, constituting 1-4% of malignant primary bone tumors. Chordomas are slow growing tumors and show aggressive local extension, multiple recurrences and metastasis. Cutaneous metastasis of chordoma is very rare. We report a case of a 61-year-old man presenting with multiple cutaneous metastasis of primary sacral chordoma.DOI:10.21276/APALM.1753References
1. Newton H. Chordoma. In: Raghavan D, Brecher ML,Johnson DH, et al, eds. Textbooks of uncommon cancer 3rd ed. Chichester: Wiley; 2006:614-625.
2. Horwitz T. Chordal ectopia and its possible relationship to chordoma. Arch Pathol. 1941; 31:354-362.
3. Chambers PW, Schwinn CP. Chordoma: a clinicopathologic study of metastasis. Am J Clin Pathol. 1979;72:765-776.
4. Su WP, Louback JB, Gagne EJ, et al. Chordoma cutis: a report of nineteen patients with cutaneous involvement of chordoma. J Am Acad Dermatol. 1993;29:63-66.
5. Collins GR, Essary L, Strauss J, et al. Incidentally discovered distant cutaneous metastasis of sacral chordoma: a case with variation in S100 protein expression(compared to the primary tumor) and review of the literature. J Cutan Pathol. 2012;39: 637-643.
6. Ruiz HA, Goldberg LH, Humphreys TR, et al. Cutaneous metastasis of chordoma. Dermatol Surg. 2000;26:259.
7. Layfield LJ. Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues. Diagn Cytopathol. 2003;28:264-271.
8. Jambhekar NA, Rekhi B, Thorat K, et al. Revisiting chordoma with brachiury ‘‘a new age’’ marker. Analysis of a validation study of 51 cases. Arch Pathol Lab Med. 2010;134: 1181-1187.
9. Gagne EJ, Su WP. Chordoma involving the skin: an immunohistochemical study of 11 cases. J Cutan Pathol. 1992;19:469-475.
10. Oakley GJ, Fuhrer K, Seethala RR. Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Mod Pathol. 2008;21:1461-1469.
2. Horwitz T. Chordal ectopia and its possible relationship to chordoma. Arch Pathol. 1941; 31:354-362.
3. Chambers PW, Schwinn CP. Chordoma: a clinicopathologic study of metastasis. Am J Clin Pathol. 1979;72:765-776.
4. Su WP, Louback JB, Gagne EJ, et al. Chordoma cutis: a report of nineteen patients with cutaneous involvement of chordoma. J Am Acad Dermatol. 1993;29:63-66.
5. Collins GR, Essary L, Strauss J, et al. Incidentally discovered distant cutaneous metastasis of sacral chordoma: a case with variation in S100 protein expression(compared to the primary tumor) and review of the literature. J Cutan Pathol. 2012;39: 637-643.
6. Ruiz HA, Goldberg LH, Humphreys TR, et al. Cutaneous metastasis of chordoma. Dermatol Surg. 2000;26:259.
7. Layfield LJ. Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues. Diagn Cytopathol. 2003;28:264-271.
8. Jambhekar NA, Rekhi B, Thorat K, et al. Revisiting chordoma with brachiury ‘‘a new age’’ marker. Analysis of a validation study of 51 cases. Arch Pathol Lab Med. 2010;134: 1181-1187.
9. Gagne EJ, Su WP. Chordoma involving the skin: an immunohistochemical study of 11 cases. J Cutan Pathol. 1992;19:469-475.
10. Oakley GJ, Fuhrer K, Seethala RR. Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. Mod Pathol. 2008;21:1461-1469.
Published
2018-04-28
Issue
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
