Basal-like breast cancer: The road less traveled.
Keywords:
Basal-like breast cancer, gene expression profile, chemotherapy
Abstract
Basal like breast cancer is a heterogeneous subtype having poor disease free and overall survival and distinct type of recurrence and metastasis, identified by gene expression profile study. Current chemotherapy fails to curtail the innate aggressive behavior in the majority of patients. The poor prognosis coupled with a lack of targeted use of therapies is reflected in the high mortality. Future research work will be directed upon better understanding of this entity for tailored therapy.References
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2) Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, et al. Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol. 2011; 24:157-67.
3) Bertucci F, Finetti P, Cervera N, Esterni B, Hermitte F, Viens P, et al. How basal are triple negative breast cancers? Int J Cancer 2008;123:236–40.
4) Turner NC, Reis-Filho JS, Russell AM, Springall RJ, Ryder K, Steele D, et al. BRCA1dysfunction in sporadic basal-like breast cancer. Oncogene. 2007; 26: 2126 -32.
5) Subhawong AP, Subhawong T, Nassar H, Kouprina N, Begum S, Vang R, et al. Most basal-like breast carcinomas dem-onstrate the same Rb−/p16+ immuno-phenotype as the HPV- related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol.2009; 33: 163-75
6) Rakha E, Reis-Filho JS. Basal-like Breast Carcinoma from Expression Profiling to Routine Practice. Arch Pathol Lab Med. 2009; 133:860-8.
7) Ellis IO, Lee AHS, Pinder SE, Rakha EA. Tumours of the breast. In: Fletcher CDM editor. Diagnostic histopathology of tumours. 4th ed. Philadelphia: Elsevier; 2013. p.1098-99.
8) Leidy J, Khan A, Kandil D. Basal-Like Breast Cancer: Update on Clinicopathologic, Immuno-histochemical, and Molecular Features. Arch Pathol Lab Med. 2014; 138:37-43.
9) Rakha E, Reis-Filho JS, Ellis IO. Impact of Basal-Like Breast Carcinoma Determination for a More Specific Therapy. Pathobiology. 2008; 75:95–103.
Published
2014-07-20
Issue
Section
Editorial
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