Spectrum of Liver Pathology in Autopsy Cases
A Study at Ajmer
Keywords:
autopsy, liver diseases, histopathology, congestion
Abstract
Background : It is a known fact that silent liver diseases are common amongst apparently healthy individuals and are sometimes diagnosed only at autopsy The underlying causes of chronic liver diseases vary in different geographic areas and are based on various factors such as socioeconomic status, life style, diet, local or regional infections, and other endemic diseases. Method : The present study was conducted in the Department of Pathology, J.L.N. Medical College, Ajmer during the period from January 2016 to September 2016 on 200 medico-legal autopsy cases brought to the mortuary Information regarding age, sex, place and previous history of any disease etc., were collected from the records and from the relatives. The liver specimens from these cases were examined grossly as well as microscopically to establish presence of liver diseases. Results: Satisfactory tissue samples for histologic evaluation were available in all the cases with a mean age of 40.78 years. Males predominated the study with a male: female ratio of 4.4: 1. Normal histology was found in 10 (6.84%) cases. Important findings included congestion in 72 (49.21), steatosis in 58 (39.72%), chronic hepatitis in 44 (30.13%), steatohepatitis in 12 (18.21%), cirrhosis in 5 (3.42%) cases, hepatic granulomas in 4 (3.8%) cases. Causes of death were: sudden deaths (35.61%), old diseass (13.69%), murder (20.53%), insecticide spillage (7.53%), Road traffic accident (5.47%), alcohol poisoning (4.79%), head injury (2.70%). Conclusion:. The study was conducted only on specimens collected from the mortuary and may not reflect the actual pattern of liver diseases in the local.References
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2. Bal MS, Singh SP, Bodal VK, Oberoi SS, Surinder K. Pathological findings in liver autopsy. Journal of Indian Academy of Forensic Medicine 2004; 26(2):971-73.
4. Sotoudehamanesh R, Sotoudeh M, Asgari A, Abedi-Ardakani B, Tavangar SM, Khakinejad A et al. Silent liver diseases in autopsies from forensic medicine of Tehran. Archives of Iranian Medicine 2006; 9(4):324-28.
3. Fubara DS, Jebbin NJ. Hepatocellular carcinoma in Port Harcourt, Nigeria.Clinicopathologic study of 75 Cases. Annals of African Medicine 2007; 6(2):54- 7.
5. Selvi RT, Selvam V, Subramanium PM. Common silent liver diseases in and around of Salem population: An autopsy study. Journal of Clinical and Diagnostic Research 2010 Apr; 6(2):207-10.
6. Merat S, Sotoudehmanesh R, Nouraie M, Peikan-Heirati M, Sepanlou SG, Malekzadeh R et al. Sampling error in histopathology findings of non alcoholic fatty liver diseases: A postmortem liver histology study. Archives of Iranian Medicine 2012 July; 7:418-20.
7. Voinova LV. Aetiological and nosological structure of liver diseases (on autopsy data of clinics of I.M. Sechenov Moscow Medical Academy in 1988-1997). Arkh patol. 2000; 62:45-47.
8. Berry CL. Liver lesions in an autopsy population. Hum Toxicol. 1987; 6: 209-214.
9. Lee YS. The pattern of liver diseases in Singapore. An autopsy study. Trop Geogr Med. 1979; 31:69-74.
10. Smita et al. Study of liver pathology in autopsy cases. International Journal of Current Research 2014 ; 6 (3) : 5795-5797.
11. Umesh Babu et al .Spectrum of liver pathology at autopsy. IJRR 2015; 2 (3):79-85.
12. Madhu Bala devi et al. Pathological findings of liver in autopsy cases, A study at Imphal. J Indian Acad Forensic Med 2013 ;35(3):206-210.
13. Zumla A, James DG. Granulomatous infections: Etiology and Classification. Clin Infect Dis. 1996;23:146-58.
14. Cunnigham D, Mills PR, Quigley EM, Patrick RS, Watkinson G, MacKenzie JF. Hepatic Granulomas: Experience over a 10-year period in the West of Scotland. Q J Med. 1982;51:162-70.
Published
2018-05-21
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