Hodgkin lymphoma with granulomas. Demystifying the dilemma
Keywords:
Hodgkin Lymphoma, Granulomatous inflammation, Epithelioid cell granuloma, malignancy
Abstract
Presence of granuloma in Hodgkin lymphoma is a common finding which is often a source of diagnostic confusion. There is no clearly defined strategy to approach this dual pathology. The present case describes a diagnostic approach using modalities like immunohistochemistry and Catridge based nucleic acid amplification test that helped reach to most likely cause of granuloma with underlying Hodgkin lymphoma.DOI:10.21276/APALM.1861References
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2. Chopra R, Rana R, Zachariah A, Mahajan MK, Prabhakar BR. Epithelioid granulomas in Hodgkin's disease--prognostic significance. Indian J Pathol Microbiol 1995; 38: 427-33.
3. de Hemricourt E, De Boeck K, Hilte F, et al. Sarcoidosis and sarcoid-like reaction following Hodgkin's disease. Report of two cases. Mol Imaging Biol 2003; 5: 15-9.
4. Jensen MK, Pulczynski S, Johansen P. Suspected malignant lymphoma presenting with widespread granulomatous lesions in bones and lymph nodes and responding to combination chemotherapy. Acta haematologica 1996; 96: 237-41.
5. Connors JM. Clinical manifestations and natural history of Hodgkin's lymphoma. Cancer J 2009; 15: 124-8.
6. Koo SE, Park CJ. Granulomatous bone marrow involvement of Hodgkin lymphoma, nodular sclerosis type. Blood Res 2017; 52: 82.
7. Dagaonkar RS, Choong CV, Asmat AB, et al. Significance of coexistent granulomatous inflammation and lung cancer. J Clin Pathol 2017; 70: 337-41.
8. Coyne JD. Colonic carcinoma with granulomatous (sarcoid) reaction. J Clin Pathol 2002; 55: 708-9.
9. Nyunt WW, Wong YP, Wan Jamaludin WF, Abdul Wahid SF. Diffuse large B cell lymphoma with chronic granulomatous inflammation. Malays J Pathol 2016; 38: 55-9.
10. Khurram M, Tariq M, Shahid P. Breast cancer with associated granulomatous axillary lymphadenitis: a diagnostic and clinical dilemma in regions with high prevalence of tuberculosis. Pathol Res Pract 2007; 203: 699-704.
11. Deen J, Banney L, Perry-Keene J. Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. J Cutan Pathol 2017 Dec 11. doi: 10.1111/cup.13076. [Epub ahead of print]
12. Bhatia A, kumar Y, Kathpalia A. Granulomatous inflammation in lymph nodes draining cancer: A coincidence or a significant association. Int J Med and Medical Sci 2009; 1: 013-6.
13. Daly PA, O'Briain DS, Robinson I, Guckian M, Prichard JS. Hodgkin's disease with a granulomatous pulmonary presentation mimicking sarcoidosis. Thorax 1988; 43: 407-9.
14. Brincker H. Interpretation of granulomatous lesions in malignancy. Acta oncologica 1992; 31: 85-9
2. Chopra R, Rana R, Zachariah A, Mahajan MK, Prabhakar BR. Epithelioid granulomas in Hodgkin's disease--prognostic significance. Indian J Pathol Microbiol 1995; 38: 427-33.
3. de Hemricourt E, De Boeck K, Hilte F, et al. Sarcoidosis and sarcoid-like reaction following Hodgkin's disease. Report of two cases. Mol Imaging Biol 2003; 5: 15-9.
4. Jensen MK, Pulczynski S, Johansen P. Suspected malignant lymphoma presenting with widespread granulomatous lesions in bones and lymph nodes and responding to combination chemotherapy. Acta haematologica 1996; 96: 237-41.
5. Connors JM. Clinical manifestations and natural history of Hodgkin's lymphoma. Cancer J 2009; 15: 124-8.
6. Koo SE, Park CJ. Granulomatous bone marrow involvement of Hodgkin lymphoma, nodular sclerosis type. Blood Res 2017; 52: 82.
7. Dagaonkar RS, Choong CV, Asmat AB, et al. Significance of coexistent granulomatous inflammation and lung cancer. J Clin Pathol 2017; 70: 337-41.
8. Coyne JD. Colonic carcinoma with granulomatous (sarcoid) reaction. J Clin Pathol 2002; 55: 708-9.
9. Nyunt WW, Wong YP, Wan Jamaludin WF, Abdul Wahid SF. Diffuse large B cell lymphoma with chronic granulomatous inflammation. Malays J Pathol 2016; 38: 55-9.
10. Khurram M, Tariq M, Shahid P. Breast cancer with associated granulomatous axillary lymphadenitis: a diagnostic and clinical dilemma in regions with high prevalence of tuberculosis. Pathol Res Pract 2007; 203: 699-704.
11. Deen J, Banney L, Perry-Keene J. Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. J Cutan Pathol 2017 Dec 11. doi: 10.1111/cup.13076. [Epub ahead of print]
12. Bhatia A, kumar Y, Kathpalia A. Granulomatous inflammation in lymph nodes draining cancer: A coincidence or a significant association. Int J Med and Medical Sci 2009; 1: 013-6.
13. Daly PA, O'Briain DS, Robinson I, Guckian M, Prichard JS. Hodgkin's disease with a granulomatous pulmonary presentation mimicking sarcoidosis. Thorax 1988; 43: 407-9.
14. Brincker H. Interpretation of granulomatous lesions in malignancy. Acta oncologica 1992; 31: 85-9
Published
2018-04-28
Issue
Section
Case Report
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