A Study on Histopathological Spectrum of Lesions in Urinary Bladder Specimens

  • Susmitha S Department of Pathology, BLDE University Shri B M Patil Medical College Hospital and Research centre Vijayapura, Karnataka, India
  • Girija S Patil Department of Pathology, BLDE University Shri B M Patil Medical College Hospital and Research centre Vijayapura, Karnataka, India
  • S B Patil Department of Urology, BLDE University Shri B M Patil Medical College Hospital and Research centre Vijayapura, Karnataka, India
Keywords: Urothelial neoplasm, Invasive urothelial carcinoma, Cystoscopic bladder biopsy, Transurethral resection of the bladder tumor (TURBT)


INTRODUCTION: Urinary bladder lesions constitute an important source of clinical signs and symptoms. Both non-neoplastic and neoplastic lesions are quite common. Neoplastic lesions are responsible for significant morbidity and mortality throughout the world. Urinary bladder cancer is 2nd most common cancer after prostate cancer in genitourinary system. Histopathological analysis of cystoscopic bladder biopsy and Transurethral resection of the bladder tumor (TURBT) material are the mainstay for cancer diagnosis. OBJECTIVE: To describe the histopathological spectrum of urinary bladder lesions in TURBT and cystoscopic biopsies. METHODOLOGY: All urinary bladder specimens were included in the study. The specimens were grossly examined and entire tissue was processed in all cases as per standard protocol. Multiple sections of 3-5 micron thickness were obtained and stained with H&E, followed by histopathological examination to classify them into non – neoplastic & neoplastic lesions on light microscopy.   RESULTS: Total 48 cases were studied, out of which 20 were cystoscopic bladder biopsies and 28 were TURBT specimens. Non-neoplastic lesions was predominantly comprised of chronic non-specific cystitis. Among the neoplastic lesions, urothelial carcinoma is the predominant type and was most commonly seen in age group of 51-80 years constituting 92.85%. These neoplastic lesions were more common among males (71.43%) with M:F ratio of 2.5:1. Invasive urothelial carcinoma was the predominant type followed by various noninvasive urothelial lesions. CONCLUSION:  Urinary bladder lesions are heterogenous and awareness regarding the various histological features of these lesions, their neoplastic potential, risk of recurrence and possible pitfalls can help pathologists for accurate diagnosis.

Author Biography

Susmitha S, Department of Pathology, BLDE University Shri B M Patil Medical College Hospital and Research centre Vijayapura, Karnataka, India
department of pathology


1. Epstein JI, Lotan TL. The Lower Urinary Tract and Male Genital System. In: Kumar V, Abbas AK, Aster JC, editors. Robbins and Cotran Pathologic Basis of Diseases.9thed. Faridabad: Elsevier; 2014. 961-9.
2. Goyal VK, Vyas SP, Kothari DC. Spectrum of Lesions in Urinary Bladder Biopsies :Histopathological Study. Int J Dent Med Res. 2015;1(6):42–6.
3. Pudasaini S, Subedi N, Prasad KBR, Rauniyar SK, Josi BR,Bhomi KK. Cystoscopic bladder biopsies :A histopathological study. Nepal Med Coll J. 2014;6(1):9–12.
4. Shruthi.HP, Rangaswamy.R. Spectrum of Lesions in Urinary Bladder Biopsies-A Histopathological Study.IJHSR. 2015 May;5(5):144-52
5. Aparna C, Thumma RR, Devi CP, Vanapalli SVRLJ, Mounika TDN. Histopathological Spectrum of Urothelial lesions- Experience of A Single Tertiary Care Institute. IJCMR. 2016;3(6):1731-3
6. Kumar MU, Yelikar BR. Spectrum of Lesions in Cystoscopic Bladder Biopsies- A Histopathological Study. Al Ameen J Med Sci. 2012;5(2):132-6.
7. Matalka I, Bani HK, Shota A, Bani HO, Bani HI. Transitional cell carcinoma of the urinary bladder: a clinicopathological study. Singapore Med J.2008;49(10):790-4.
8. Wood DP. Tumors of Bladder. In: WeinJA, Kavoussi RL, Partin WA, Peters CA editors. Campbell-Walsh Urology.11thed. China: Elsevier; 2016. 2184-204.
9. Felix AS, Soliman AS, Khalad H, Zaqhloul MS, Banerjee M, El-Baradie Met al. The changing patterns of bladder cancer in Egypt over the past 26 years. Cancer Causes Control. 2008 May;19(4):421–9.
10. Jecu M, Geavlete B, Multescu R, Stanescu F, Moldoveanu C, Adou L et al. NBI cystoscopy in routine urological practice- from better vision to improve therapeutic management. J Med Life. 2014 June 15;7(2):282-6
11. Grandhi B, Byna SSR, Shanthi V, Vydehi BV, Rao NM, Goel A. Histopathological Spectrum of Urothelial Lesions. IOSR-JDMS. 2016;15(6):4-7.
12. Shah PY, Nanavati M, Patel RG, Goswami HM. Spectrum of lesions in urinary bladder- A histopathological study. Int J Cur Res Rev. 2016;8(4):19-24.
13. Srikousthubha, Sukesh, Raghuveer CV, Hingle S. Profile of Lesions in Cystoscopic Bladder Biopsies: A Histopathological Study. J Clin Diagn Res. 2013 Aug;7(8):1609-12.
14. Chinnaswamy R, Krishnamoorthy S, Joseph L, kumaresan N, Ramanan V. Clinico-pathological Study of Bladder Cancer in a Tertiary Care Centre of South India and Impact of Age, Gender, and Tobacco in Causing Bladder Cancer: A Single Centre Experience. Int J Sci Stud. 2016;3(10):72-7.
15. Laishram RS, Kipgen P, Laishram S, Khuraijam S, Sharma DC. Urothelial Tumors of the Urinary Bladder in Manipur: A Histopathological Perspective. Asian Pacific J Cancer Prev. 2012;13:2477-9.
16. Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of tumours of the Urinary System and Male Genital Organs- Part B: Prostate and Bladder Tumours. Eur Urol. 2016 July;70(1):110-5.
Original Article