Neoplastic Lesions of Small and Large Intestine- A Prospective Study in Tertiary Care Hospital

  • Venkata Kalyan Nunna
  • Prabhu M H
  • S. S. Inamdar
  • Mallikarjun Pattanashetti
  • Rachana L Y
Keywords: Histopathological study, Gastrointestinal Tumors, Biopsy


Background: This study was carried out to study the occurrence, evaluate and correlate various histopathologic types of tumors at different sites of gastrointestinal tract in relation to age and sex of the patients operated in Surgery department and specimens received at Pathology department of S.Nijalingappa Medical college, Bagalkot, Karnataka. Methods : A cross sectional histopathological study of gastrointestinal tumors of 45 cases was carried out on surgical specimens and biopsy received from Department of Surgery, S.Nijalingappa Medical College, Bagalkot from January 2016 to July 2017. Specimen were preserved in 10% buffered formalin. It was kept in 10% buffered formalin for proper fixation, subsequently dehydration, clearing, embedding in paraffin wax was carried out. Blocks were made and sections of 3µm thickness were cut and stained with Haematoxylin and Eosin stain and slides were reported. Results: : A total of 45 cases were included, among which 26 were males and 19 were females  with peak occurrence in sixth decade.The following is  anatomical distribution : Small intestine 7(15.5%), Appendix 0(0%), Colon & Rectum 37 (82.2%) and Anal canal 01(2.2%).Histological types seen were - Epithelial 41(91.1%), Mesenchymal 03 (6.6%) and Lymphoma 01(2.2%). Conclusion: Gastrointestinal tumors show a wide variation in the morphology.Hence, histopathological examination is must for the diagnosis and classification  of these tumors. The occurrence of gastrointestinal tumors was mostly in the colon and rectum.This study emphasises the need for early diagnosis of the disease through histopathology, which when correlated clinically will help the clinician to implement the appropriate treatment and improve the survival of the patients.


1) Turner J R. The Gastrointestinal Tract. In: Vinay Kumar, Abul Abbas and Jon Aster. Robbins
and Cotran Pathologic Basis of Disease; 9th Edition. Elsevier Health Sciences. London,
2) Norio Matsukura, Hiroko Ohgaki, Rens Lambert. World Cancer Report,Lyon,France, IARC
Press. 2003:194-202.
3) Mohammad A, Makaju R. Retrospective histopathological analysis of various neoplasms
of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching
Hospital. Nepal. Kathamandu University Medical Journal 2005;4:474-8.
4) Bosman F.T, Carnerio F, Hruban R.H, Theise N.D. Pathology and Genetics. Tumors of
Digestive system. WHO classification of tumors, 4th Edition, Lyon, France: IARC Press
International Agency for Research on Cancer 2010:210-31.
5) Hornick L.J. Tumor of the small and large intestines, including anal region. In: Christopher
Fletcher. Fletcher’s Histopathology of Tumors. 4th Edition. Volume 1. Churchill Livingstone.
Elsevier Health Sciences. London 2013; 434-76.
6) Sharma P, Deka M. A Study of Neoplastic Lesions of Colorectum in a Tertiary Care Hospital.
Int J Sci Stud. 2015;3(8):88-91.
7) Assem O. et al. Primary gastrointestinal cancers in the Western Region of Saud Arabia.
Saudi Medical Journal. 2000;21(8):730-4.
8) Patel MM, Gamit B, Patel PR. Analysis of gastrointestinal malignancy: A Five Years
study. National Journal of Community Medicine. 2012;3(3):555-7.
9) Shahid J, Nadira M, Sajid M, Muhammad L. Analysis of Gastrointestinal malignancy at
Armed Forces Institute of Pathology, Ravalpindi, Pakistan. Asian pacific journal of
cancer prevention 2005;6:497-500.
10) KK Leena Devi, N Suvarna. Patterns of Gastrointestinal tumors in North Kerala. Indian
Journal of Cancer 1980;17:159-63.
11) Nannavati MG, Parikh JH, Gamit KS, Modh SD. A Histopathological Study of Intestinal
Lesions. International Journal of Science and Research 2014;3(9):326-30 .
Original Article