Squamoid Eccrine Ductal Carcinoma: A Diagnostic
Keywords:
Squamoid, Eccrine, Ductal, Carcinoma, p63, CEA
Abstract
Eccrine carcinomas comprise less than 0.01% of all cutaneous malignancies. Squamoid eccrine ductal carcinoma is an exceedingly rare variant that exhibits both squamous and eccrine ductal characteristics. It presents in patients older than 50 years on the head, neck, and trunkas nodule or plaque. It is commonly misdiagnosed as squamous cell carcinoma from which it must be differentiated as its recurrence and metastasis rates are much higher.Very few cases have been reported, we hereby report an additional case of this rare tumor. A 50 years old male presented with a slow-growing nodule in the frontal region of scalp since one year. Histopathology showed a dermal based infiltrativeepithelial tumor with extensive squamous differentiation arranged in interlacing cords and nests, with focal formation of ductal lumina which was highlighted by immunohistochemistry. The diagnostic identification of eccrine carcinomas is hampered by their rarity .Awareness of this rare entity will help in accurate diagnosis and management.References
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6. Herrero J, Monteagudo C, Jordá E, Llombart-Bosch A. Squamoid eccrine ductal carcinoma. Histopathology 1998 ;32(5):478-80.
7. Magro C, Glass S. Squamoid Eccrine Ductal Carcinoma. The Dermatologist 2016 ;24(5)
8. Antley CA, Carney M, Smoller BR. Microcystic adnexal carcinoma arising in the setting of previous radiation therapy. J Cutan Pathol 1999; 26: 48–50.
9. Qureshi HS, Ormsby AH, Lee MW, Zarbo RJ, Ma CK. The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas. J Cutan Pathol 2004; 31: 145–52.
10. Wang B, Jarell AD, Bingham JL, Bonavia GH. PET/CT imaging of squamoid eccrine ductal carcinoma. Clin Nucl Med 2015 ;40(4):322-4.
2. Jung YH, Jo HJ, Kang MS. Squamoid eccrine ductal carcinoma of the scalp. Korean J Pathol2012; 46(3): 278-81.
3. Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid eccrine ductal carcinoma: a case report and review of the literature. Am J Dermatopathol 2010 ;32(3):287-92.
4. Wick MR, Goellner JR, Wolfe JT 3rd, Su WP. Adnexal carcinomas of the skin. Eccrine carcinomas. Cancer 1985 ;56(5):1147-62.
5. Wildemore JK, Lee JB, Humphreys TR. Mohs surgery for malignant eccrine neoplasms. Dermatol Surg 2004 ;30:1574-9.
6. Herrero J, Monteagudo C, Jordá E, Llombart-Bosch A. Squamoid eccrine ductal carcinoma. Histopathology 1998 ;32(5):478-80.
7. Magro C, Glass S. Squamoid Eccrine Ductal Carcinoma. The Dermatologist 2016 ;24(5)
8. Antley CA, Carney M, Smoller BR. Microcystic adnexal carcinoma arising in the setting of previous radiation therapy. J Cutan Pathol 1999; 26: 48–50.
9. Qureshi HS, Ormsby AH, Lee MW, Zarbo RJ, Ma CK. The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas. J Cutan Pathol 2004; 31: 145–52.
10. Wang B, Jarell AD, Bingham JL, Bonavia GH. PET/CT imaging of squamoid eccrine ductal carcinoma. Clin Nucl Med 2015 ;40(4):322-4.
Published
2018-08-27
Issue
Section
Case Report
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