Variation of Platelet Indices Among Patients with Acute Stroke and the Need for their Routine Documentation
Keywords:
PLATELET INDICES, STROKE, ISCHEMIC, HEMORRHAGIC, PLATELETS
Abstract
Background: Acute Stroke is characterized by sudden appearance of focal deficit of brain function most commonly hemiplegia, which may be accompanied by higher centre dysfunction, sensory loss and visual field defects. Based on the pathology, it is classified as Ischemic or Hemorrhagic stroke. In both the conditions, there is an inevitable involvement of platelets. In the former, platelet activation leading to a thrombus formation is the pathogenic feature whereas in the latter, platelet activation to stop the bleeding is seen.In this study we aim to find the association between Platelet Count, Platelet Indices; Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Stroke. Methods: It was a prospective study done in which 70 consecutive patients were divided into ischemic and hemorrhagic strokes. Proper Exclusion criteria were carried out and the patients’ blood samples were taken. Platelet indices were measured with a SYSMEX analyser. Statistical analysis was done using 2 sample T Tests using SPSS software. Result: The Parameters MPC, MPV and PDW all showed a significant association (P=0.04, P=0.00, P=0.00 respectively) between the stroke patients and control group. Furthermore, a significant difference was found between MPC of patients with ischemic and hemorrhagic stroke (P=0.025). Conclusion: Platelet Indices are altered in patients with Stroke when compared to normal patients with no history of CAD or CVD or other lifestyle diseases. Further studies and researches have to be undertaken to see if Platelet Indices are indeed a worthy prognostic tool.References
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9. Giovanetti T, Nascimento A. Platelet Indices: Laboratory and Clinical Applications. Revista Brasileira de Hematologia e Hemoterapia 2011 33(2):164-165
10. Pizzuli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina and non-cardiac chest pain. European Heart Journal, 1998; 19: 80–84
11. Enticknap JB, Gooding PG, Lansley TS. Platelet size and function in ischemic heart disease. Atherosclerosis Research 1969; 10: 41-49.
12. Jagroop IA, Mikhailidis DP. Mean platelet volume is an independent risk factor for myocardial infarction, but not for coronary artery disease. British Journal of Haematology 2003; 120: 166-71.
13. Dougherty JH, Levy DE, Weksler BB. Platelet activation in acute cerebral ischemia. Lancet 1997; 1: 821-824.
14. Toghi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation and ATP release in cerebral thrombosis. Stroke 1991; 22: 17-21
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16. Phillip Bath. Acute stroke. In: David Machin, Simon Day, Sylvan Green (Ed). Textbook of clinical Trials. Wiley 2006;179-180.
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19. Mdlley TO, Langhorne P, Elton RA, Steward C. Platelet size in stroke patients. Stroke 1995; 26: 995-99
20. Al-Tameemi W, Ameen MM. Significance of Platelet Indices in Patients with Acute Ischemic Stroke. The Iraqui Journal of Agricultural Sciences. 2012 vol 10 (4):383-389
21. Shah P, Mir R, Kamili M. Role of Mean Platelet Volume in Ischemic Stroke. JK science 2013 Volume 15 (3): 136-139
22. Ghahremanfard F, Asghari N, Ghorbani R. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences 2013; Vol. 18 (2): 147-151
23. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-61.
24. Jackson SR, Carter JM. Platelet volume: laboratory measurement and clinical application. Blood Rev. 1993;7(2):104-13.
25. Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets.1998;9(6):359-64
2. Machlus KR; Thon JN; Italiano JE. Interpreting the developmental dance of the megakaryocyte: A review of the cellular and molecular processes mediating platelet formation". British Journal of Haematology. 2014; 165 (2): 227–36.
3. Jain NC. A scanning electron microscopic study of platelets of certain animal species. Thrombosis et diathesis haemorrhagica.1975 33 (3): 501–7.
4. Michelson D, Platelet Structure. ln: James G White, Editors. Platelets. Elsevier 2013, p. 117-118
5. Matarrese P; Straface E; Palumbo G. Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A—activation and long-term commitment to cell death. FEBS Journal.2009 276 (3): 845–56.
6. Jagroop IA, Tsiara S, Mikhailidis DP. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2003; 14: 335-6.
7. Tsiara S, Elisaf M, Jagroop IA, et al. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clinical and Applied Thrombosis/Hemostasis. 2003; 9: 177-90.
8. Jakubowski JA, Thomson CB, Vaillancourt R, et al. Arachidonic acid metabolism by platelets of differing size. British Journal of Haematology 1983; 53: 503-511.
9. Giovanetti T, Nascimento A. Platelet Indices: Laboratory and Clinical Applications. Revista Brasileira de Hematologia e Hemoterapia 2011 33(2):164-165
10. Pizzuli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina and non-cardiac chest pain. European Heart Journal, 1998; 19: 80–84
11. Enticknap JB, Gooding PG, Lansley TS. Platelet size and function in ischemic heart disease. Atherosclerosis Research 1969; 10: 41-49.
12. Jagroop IA, Mikhailidis DP. Mean platelet volume is an independent risk factor for myocardial infarction, but not for coronary artery disease. British Journal of Haematology 2003; 120: 166-71.
13. Dougherty JH, Levy DE, Weksler BB. Platelet activation in acute cerebral ischemia. Lancet 1997; 1: 821-824.
14. Toghi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation and ATP release in cerebral thrombosis. Stroke 1991; 22: 17-21
15. Hartona S. Experiences from a multicenter Stroke register: a preliminary report. Bulletein of World Health Organisation 1976;54:541-53.
16. Phillip Bath. Acute stroke. In: David Machin, Simon Day, Sylvan Green (Ed). Textbook of clinical Trials. Wiley 2006;179-180.
17. Richard S. Snell (2006). Clinical neuroanatomy, 6. ed. Lippincott Williams & Wilkins, Philadelphia. pp. 478–485.
18. Konkle B A, Disorders of Platelets and Vessel Wall ln: Kasper, Fauci, Loscalzo Editors, Harrison’s Principles of Internal Medicine (19th edition), McGraw Hill, p 725-732
19. Mdlley TO, Langhorne P, Elton RA, Steward C. Platelet size in stroke patients. Stroke 1995; 26: 995-99
20. Al-Tameemi W, Ameen MM. Significance of Platelet Indices in Patients with Acute Ischemic Stroke. The Iraqui Journal of Agricultural Sciences. 2012 vol 10 (4):383-389
21. Shah P, Mir R, Kamili M. Role of Mean Platelet Volume in Ischemic Stroke. JK science 2013 Volume 15 (3): 136-139
22. Ghahremanfard F, Asghari N, Ghorbani R. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences 2013; Vol. 18 (2): 147-151
23. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-61.
24. Jackson SR, Carter JM. Platelet volume: laboratory measurement and clinical application. Blood Rev. 1993;7(2):104-13.
25. Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets.1998;9(6):359-64
Published
2018-05-21
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