Role of p63 in Breast Carcinoma

A Review

  • Akriti Kashyap Santara Institute of Aerospace Medicine, Bengaluru, India
  • Ashwini Kumar Institute of Aerospace Medicine, Bengaluru, India
  • Brajesh Singh Command Hospital, Kolkata, India
  • Rohini Doshetty Institute of Aerospace Medicine, Bengaluru, India
Keywords: p63, breast, carcinoma, diagnostic, metaplastic


p63, a recently identified member of the p53 gene family, is located on chromosome 3 q27. It has recently been proven that p63 plays an important role in the progression of ductal carcinoma in situ to infiltrating ductal carcinoma.p63 had two isoforms-one of which TA p63 which induces apoptosis and the other Np63 enhances cell proliferation and inhibits apoptosis. Also, matrix metalloproteinase, which contributes to the invasive capacity of cancer cells is a direct transcriptional target of p63. Much research is required to elucidate the functions of isoforms of p63. p63 has diagnostic utility in breast carcinomas.p63 is documented to be specific for metaplastic carcinomas with spindle and /or squamous areas.p63is also a part of the trichromogen cocktail stain commonly used to solve diagnostic dilemmas in breast pathology. This nuclear marker with strong and diffuse staining pattern on immunohistochemistry is easily detectable, hence should be used in the diagnostic workup of challenging spindle cell tumors of the breast. Thus in this article, the various functions and uses of p63 in breast carcinoma have been brought out. The diagnostic potential of p63 in other tumors and sarcomas still needs to be researched.

Author Biographies

Akriti Kashyap Santara, Institute of Aerospace Medicine, Bengaluru, India
Air Force Pathologist (Rank Squadron leader) at Department of Aviation Pathology and Toxicology
Ashwini Kumar, Institute of Aerospace Medicine, Bengaluru, India
Dept of Biochemistry
Brajesh Singh, Command Hospital, Kolkata, India
Rohini Doshetty, Institute of Aerospace Medicine, Bengaluru, India
Dept of Pathology


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Review Article