Expression of Estrogen and Progesterone Receptor Status in Breast Carcinoma Using Quick Score
A Study at a Tertiary Care Centre in Kerala
Keywords:
Breast cancer, Immunohistochemistry, Estrogen receptor, Progesterone receptor, Bloom Richardson Grading, Quick score
Abstract
Background : Breast carcinoma is the most common malignant tumour and the leading cause of carcinoma death in women. The hormone receptor status is important nowadays due to its prognostic and therapeutic significance. The objective of this study was to correlate estrogen (ER) and progesterone receptor (PR) status with clinicopathological parameters like age, lymphnode status, size of the tumour and tumour grade of breast carcinoma. Methods : This study was conducted in the Department of Pathology, Government Medical College, Thrissur from January 2012- June 2013. 100 mastectomy specimens were received and analysed for both histological grading and immunohistochemically by quick score for ER and PR markers. Results : Majority of the cases were between 50-60 years of age with invasive ductal carcinoma grade 2. ER, PR positivity in this study was 67% and 62% respectively with both receptors positive for 61% of cases. In this study 55% showed no axillary lymphnode involvement and 45% showed lymphnode involvement with majority cases had size between 2 and 5 cm.References
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17) Christopher I. Li, Benjamin O, Anderson, Daling JR, Moe RE. Trends in Incidence Rates of Invasive Lobular and Ductal Breast Carcinoma. JAMA 2003;289(11):1421-142
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2) Rhodes A, Jasani B, Balaton AJ, Barnes DM, Miller KD. Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas: Correlation with patient age, assay sensitivity, threshold value, and mammographic screening. J Clin Pathol 2000;53:688-96.
3) Leake R, Barnes D, Pinder S, Ellis I, Anderson L, et al. Immunohistochemical detection of steroid receptors in breast cancer: A working protocol. J Clin Pathol 2000;53:634-5.
4) "World Cancer Report". International Agency for Research on Cancer. 2008. http://www.iarc.fr/en/publications/pdfsonline/wcr/2008/wcr_2008.pdf. Retrieved 2011-02-26.
5) "Breast cancer: prevention and control" World Health Organization 2008
6) Li CI, Darling JR, Malone KE. Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998. J Clin Oncol 2003;21:28-34.
7) Pleşan DM, Georgescu M, Georgescu CV, Pătrană N, et al Immunohistochemical evaluation of hormone receptors with predictive value in mammary carcinomas Rom J Morphol Embryol 2011, 52(4):1331–1336
8) Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, et al. Hormone receptor status of breast cancer in India: A study of 798 tumours. Breast 2000;9:267-70
9) Sughayer MH, Al-Khawaja M, Massarweh S, Al-Masri M. Prevalence of hormone receptors and HER2/neu in breast cancer cases in Jordan. Pathol Oncol Res 2006;12:83-6.
10) Sofi GN, Sofi JN, Nadeem R, Shiekh RY, Khan FA, et al . Estrogen receptor and progesterone receptor status in breast cancer in relation to age, histological grade, size of lesion and lymph node involvement. Asian Pac J Cancer Prev. 2012;13(10):5047-52.
11) Fatima et al. Breast cancer: steroid receptors and other prognostic indicators. J Coll Physicians Surg Pak. 2005;15, 230-3.
12) Kuraparthy S, Reddy KM, Yadagiri LA, et al. Epidemiology and patterns of care for invasive breast carcinoma at a community hospital in Southern India. World J Surg Oncol, 2007:5, 56
13) Mudduwa K.B. Quick score of hormone receptor status of breast carcinoma: Correlation with the other clinicopathological prognostic parameters Indian J Pathol Microbiol 2009,52:159-63.
14) Shet et al. Hormone receptors over last 8 years in a cancer referral center in India: What was and what is? Indian J Pathol and Microbiology, 2009:52, 171-4
15) Dunnwald LK, Rossing MA, Li CI. Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients. Breast Cancer Res, 2007:9,R6
16) Kakarala M, Rozek L, Cote M, Liyanage S, Brenner DE. Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S. - a SEER analysis. BMC Cancer, 2010:10, 191.
17) Christopher I. Li, Benjamin O, Anderson, Daling JR, Moe RE. Trends in Incidence Rates of Invasive Lobular and Ductal Breast Carcinoma. JAMA 2003;289(11):1421-142
18) Jalava1 P, Kuopio T, Huovinen R, Laine J. et al. Immunohistochemical Staining of Estrogen and Progesterone Receptors: Aspects for Evaluating Positivity and Defining the Cutpoints Anticancer Research 25: 2535-2542 (2005) 50 Breast Cancer Res. 2007; 9(1): R6
19) Rakha EA, El-Sayed ME, Andrew R. Prognostic markers in triple-negative breast cancer 2007:109,25–32
20) Ann S, Andries R, Ann B, Hans W, Patrick N et al Impact of tumor chronology and tumor biology on lymph node metastasis in breast cancer. SpringerPlus 2013, 2:480
21)Hussain GA, Mohammed AA and Abdullah KA. Correlations of Hormone Receptors (ER and PR), Her2/neu and p53 Expression in Breast Ductal Carcinoma Among Yemeni Women. The Open Cancer Immunology Journal, 2011, 4, 1-9
22) Leonel F.H, Mariana CM, Xiudong L et al. A. Nodal Status and Clinical Outcomes in a Large Cohort of Patients With Triple-Negative Breast Cancer Volume 29 Number 19 July 1 2011
23)Foulkes WD, Grainge MJ, Rakha EA, et al: Tumor size is an unreliable predictor of prognosis in basal-like breast cancers and does not correlate closely with lymph node status. Breast Cancer Res Treat 117:199-204, 2009
Published
2018-06-22
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