The Frequency and Distribution of Female Genital Tract Malignancies in a Multispecialty Hospital,in Delhi

  • Qury Sabita Mahapatra ESIC Dental College & Hospital, Rohini, Delhi,India
  • Sangeeta Lamba Department of Pathology , ESI Hospital, Rohini, Delhi,India
  • Annu Nanda Department of Pathology ESIC Dental College & Hospital, Rohini, Delhi, India
  • Divya Sethi Department of Pathology , ESI Hospital, Rohini, Delhi,India
  • Sonam L Jain , ESI Hospital, Rohini, Delhi
Keywords: Female Genital Tract, Malignancy, Prevalence


Background: The most common malignancy in women is breast carcinoma worldwide.  However cancers of the female genital tract are still an important cause of cancer morbidity and mortality.  They are the next commonest malignancy after breast cancer in women. Aim: A hospital based study was conducted to determine the type and frequency of genital tract malignancies in women in multispecialty hospital in Delhi Material and methods: Data from records of surgical biopsy & resection specimens along with demographic data for 3yrs of all the female patients with malignant lesions were included in the study.  The distribution and prevalence of malignancies of female genital tract were analyzed. Results:  A total of 118 female patients diagnosed with malignancy were included in this study. Of these 50 cases had breast carcinoma, 48 cases had carcinoma of genital tract and 20cases had others including   carcinoma of oral cavity, salivary gland, thyroid, lymphomas, and GIT carcinoma. Cervical carcinoma (83.3%) was the most common gynecological malignancy followed by the ovary (10.4%) & then endometrial carcinoma (6.25%). Most common age group affected by cervical carcinoma was 51-60yrs. Moderately differentiated squamous cell carcinoma was the most common grade of cervical carcinoma noted. Conclusion:  Cervical carcinoma was the most common gynecological malignancy in our study. Efforts should be made to reduce cancer burden by focus on health education of the masses, routine screening programmes for detection of cancers in females & establishing centres for monitoring & evaluation of these programmes.

Author Biographies

Qury Sabita Mahapatra, ESIC Dental College & Hospital, Rohini, Delhi,India
Assistant professor. Department of Pathology
Sangeeta Lamba, Department of Pathology , ESI Hospital, Rohini, Delhi,India
Senior Specialist & HOD, department of Pathology
Annu Nanda, Department of Pathology ESIC Dental College & Hospital, Rohini, Delhi, India
Professor & HOD, Pathology
Divya Sethi, Department of Pathology , ESI Hospital, Rohini, Delhi,India
Specialist, Deparment of Pathology
Sonam L Jain, , ESI Hospital, Rohini, Delhi
Senior Resident , Department of Pathology


1. Ferly J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008 v2.0. Cancer incidence and mortality worldwide: IARC Cancer Base No.10. Available from:
2. Ferlay J, Soerjomataram I, Diskshit R, Eser S, Mathers C, Rebelo M, et al.Cancer Incidence and Mortality Worldwide: sources, methods and major patterns in GLOBOCAN 2012 Int J Cancer 2015;136:359-86.
3. Devi KU. Current status of gynaecological cancer care in Indian J Gynecol Oncol 2009;2:77-80.
4. Basile S, Angioli R, Manci N, Palaia I, Plotti F, Benedetti panici P. Gynecological cancers in developing countries: The challenge of chemotherapy in low-resource setting. Int J Gynecol Cancer 2006;16:1491–7.

5. Kaarthigeyan K. Cervical cancer in India and HPV vaccination. Indian J Med Paediatr Oncol 2012; 33: 7–12.

6.National Cancer Registry Program . Ten year consolidated report of the Hospital Based Cancer Registries, 1984–1993, an assessment of the burden and care of cancer patients. New Delhi: Indian Council of Medical Research; 2001.

7. Agarwal G, Ramakant P. Breast cancer care in India. The Current Scenario & the
Challenges for the Future. Breast care 2008; 3:21-7.

8. Nandakumar A, Ramnath T, Chaturvedi M. The magnitude of cancer cervix in India. Indian J Med Res 2009; 130:219–21
9.Chhabra S, Sonak M, Prem V, Sharma S. Gynaecological malignancies in a rural institute in India. J Obstet Gynaecol 2002; 22: 426-9.

10. Dhakal HP, Pradhan M. Histological pattern of gynaecological cancers. J Nepal Med Assoc 2009; 48:301-5.

11. Nandakumar A, Anantha N, Dhar M, Ahuja V, Kumar R, Reddy S, et al. A case control investigation of cancer of the ovary in Bangalore, India. Int J Cancer 1995;63:361-5.

12.Megafu U. Cancer of genital tract among Ibo women in Nigeria. Cancer 1979;44:1875-8.

13. Rastogi T, Devesa S, Mangtani P, Mathew A, Cooper N, Kao R, et al. Cancer incidence rates among South Asians in four geographic regions:India, Singapore, UK and US. Int J Epidemiol 2008; 37:147-60.

14.ICO Information Centre on HPV and cancer (Summary Report 2014-08-22).Human Papillomavirus and Related Diseases in India. 2014

15. Ellenson LH, Pirog EC. The Female Genital Tract.In: Robbins and Cotran Pathologic basis of disease.8th edn. Philadelphia: Elsevier Saunders, 2010; 1005-63.
16. Paavonen J, Naud P, Salmeron J, Wheeler CM, Chow SN, Apter D etal. Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infections and pre-cancer which are caused by the oncogenic HPV types (PATRICIA): final analysis of a doubleblind, randomised study in young women. Lancet 2009;25:301-14.

17. Cole P, Morrison AS. Basic issues in population screening for cancer. J Natl Cancer Inst 1980;6:1263-72.
18. Jamal S, Mamoon N, Mushtaq S, Luqman M, Moghal S. The pattern of gynecological malignancies in 968 cases in Pakistan. Ann Saudi Med 2006; 26:382-4.

19. Okeke TC, Onah N, Ikeako LC, Ezenyeaku CCT.The frequency and pattern of female genital tract malignancies at the University of Nigeria Teaching Hospital, Enugu, Nigeria. Ann Med Health Sci Res 2013; 3:345-8.
20. Jacques Ferlay, et al., GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide, IARC Cancer Base No. 5, version 2.0 (Lyon, France:IARC, 2004).
21.Talukder SI, Haque MA, Alam MO, Huq MH,Roushan A, Jahan MK, et al. Gynaecological cancers in surgical specimens in Mymensingh,Bangladesh, 2006. Bangladesh J Pathol 2008;23:2-4.

22. Ahmad Z, Kayani N, Hasan SH. Histological pattern of ovarian neoplasm. J Pak Med Assoc 2000;50:416-9.

23. Miller BE. Ovarian Cancer In: Ling FW, Duff P, editors.Obstetrics and gynecology principles for practice, New York:McGraw‑Hill Companies; 2001. p. 1298‑314

24. Epstein E, Valentin L. Rebleeding and endometrial growth in women with postmenopausal bleeding and endometrial thickness less than 5mm managed by dilatation and curettage or ultrasound follow up: a randomized controlled study. Ultrasound Obstet Gynaecol 2001;18:499–504.
25. Khursheed F, Jatoi N, Das CM. Genital tract malignancies in postmenopausal women. J Ayub Med Coll Abbottabad 2010;22:32–4.
26. Seleye-Fubara-D, Uzoigwe SA, Akani CI. Pathology of vaginal cancers in Port Harcourt, Nigeria. A 14-year study. Niger J Clin Pract 2007;10:330.
Original Article