Primary Large Cell Neuroendocrine Carcinoma of Buccal Mucosa
A Report of a Case at an Unusual Location
Keywords:
Intraoral, Large Cell neuroendocrine carcinoma, Buccal mucosa
Abstract
Neuroendocrine carcinoma is a poorly differentiated carcinoma that usually occurs in the lung. Large cell neuroendocrine carcinoma is a Non-small cell lung carcinoma that shows histological features of neuroendocrine morphology (including rosettes and peripheral palisading) and expresses immunohistochemical neuroendocrine markers. Oral cavity is an exceedingly rare site for primary Neuroendocrine Carcinoma. This case report describes Primary Large Cell Neuroendocrine Carcinoma (LCNEC) of buccal mucosa and lower gingiva in a 65 years old male. To the best of the author’s knowledge this is the third case of intraoral LCNEC & second case with LCNEC in buccal mucosa to date in English literature. Thus far, only a small number of cases of intraoral mucosal Neuroendocrine carcinoma have been reported and no definitive standard treatment strategy has been determined.References
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2. Mills, S.E. Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas. Modern Pathology, 2002:15, 264-278.
3. Hull MT, Eble JN, Warfel KA. Extrapulmonary oat-cell carcinoma of the tongue: An electron-microscopic study. J Oral Pathol. 1984;13:489–96.
4. Kusafuka K, Asano R, Kamijo T, et al. Large cell neuroendocrine carcinoma of the tongue base: Case report of an unusual location with immunohistochemical analysis. Int J Oral Maxillofac surg, 2009 Mar;38(3):296-9.
5. Krishnamurthy A, Vaidhyanathan A, Majhi U. Large cell neuroendocrine carcinoma of the retromolar trigone. J Can Res Ther 2011;7:343-6
6. Adel K. El-Naggar, John K.C. Chan, Jennifer R. Grandis, Takashi Takata, Pieter J. Slootweg. WHO Classfication of Head and Neck Tumours. 4th Edition. International Agency for Research on Cancer (IARC), Lyon, France. 2017
7. Bishop JA, Westra WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol 2011 nov;35:1679-84
8. Hatoum GF, Patton B, Takita C, et al. Small cell carcinoma of the head and neck: the University of Miami experience. Int J Radiat Oncol Biol Phys 2009 june 1;74(2):477–81.
9. Jiang SX, Kameya T, Shoji M, et al. Large cell neuroendocrine carcinoma of the lung: A histologic and immunohistochemical study of 22 cases. Am J Surg Pathol.1998 May; 22(5):526‑37
10. Travis WD, Linnoila RI, Tsokos MG,et al. Neuroendocrine tumors of the lung with proposed criteria for large‑cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases. Am J Surg Pathol.1991 jun(6);15:529‑53
11. Barrett AW, Cort EM, Patel P, Berkovitz BK. 2000. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. Arch Oral Biol 45:879–887
Published
2018-09-22
Issue
Section
Case Report
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