Progressive Transformation of Germinal Centers

A Mimicker of Lymphoma

  • Sumaya . Belagavi institute of medical sciences, Belagavi, India
  • Meena N Jadhav Belagavi Institute of Medical Sciences, Belagavi, India
  • Rashmi K Patil Belagavi Institute of Medical Sciences, Belagavi, India
  • Shreekant K Kittur Belagavi Institute of Medical Sciences, Belagavi, India
Keywords: Follicular lymphoma, Hodgkin’s lymphoma, Lymph node, Progressive transformation of germinal centers.

Abstract

Progressive transformation of germinal centers (PTGC) is an uncommon variant of non-specific reactive follicular hyperplasia. PTGC is a clinically asymptomatic condition characterised by persistent lymphadenopathy. PTGC may occur before, concurrently with or after the onset of nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL). It may also be confused for follicular lymphoma and mantle zone lymphoma. We report an interesting case of PTGC in a 23 year female with swelling in the left side of neck of one year duration. Histology revealed PTGC, which was confirmed by immunohistochemistry which showed CD3+, CD20+ in appropriate B and T cell region and negative for CD15, CD30 and bcl-2. As PTGC mimics lymphoma, it should be followed up carefully.

Author Biography

Sumaya ., Belagavi institute of medical sciences, Belagavi, India
Department of Pathology

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Published
2018-09-22
Section
Case Report